Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">
									Time<br/>(Hrs.)</td><td align="center" colspan="3">                  Area (<svg height="11.125" id="M10" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.125" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" id="x1D45B"></path></g><g transform="matrix(.017,-0,0,-.017,13.305,10.862)"><path d="M535 323h-483v50h483v-50zM535 138h-483v50h483v-50z" id="x3D"></path></g><g transform="matrix(.017,-0,0,-.017,28.008,10.862)"><path d="M285 378v-2q65 -13 102 -54.5t37 -97.5q0 -57 -30.5 -104.5t-74 -75t-85.5 -42t-72 -14.5q-31 0 -59.5 11t-40.5 23q-19 18 -16 36q1 16 23 33q13 10 24 0q58 -51 124 -51q55 0 88 40t33 112q0 64 -39 96.5t-88 32.5q-29 0 -64 -11l-6 29q77 25 118 57.5t41 84.5
q0 45 -26.5 69.5t-68.5 24.5q-67 0 -120 -79l-20 20l43 63q51 56 127 56h1q66 0 107 -37t41 -95q0 -42 -31 -71q-22 -23 -68 -54z" id="x33"></path></g>
</svg>)</td><td align="center" colspan="3">           Result %</td></tr><tr class="thead"><td align="center">CPM<br/>2 (<i>μ</i>g/mL)</td><td align="center">IBU<br/>100 (<i>μ</i>g/mL)</td><td align="center">PHE<br/>5 (<i>μ</i>g/mL)</td><td align="center">CPM</td><td align="center">IBU</td><td align="center">PHE</td></tr><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td align="left">0</td><td align="center">61521</td><td align="center">4158429</td><td align="center">124685</td><td align="center">100</td><td align="center">100</td><td align="center">100</td></tr><tr><td align="left">3</td><td align="center">61009</td><td align="center">4146734</td><td align="center">123619</td><td align="center">99.16</td><td align="center">99.14</td><td align="center">99.14</td></tr><tr><td align="left">6</td><td align="center">60913</td><td align="center">4116520</td><td align="center">121706</td><td align="center">99.01</td><td align="center">98.99</td><td align="center">97.61</td></tr><tr><td align="left">24</td><td align="center">60157</td><td align="center">4104629</td><td align="center">120648</td><td align="center">98.71</td><td align="center">98.70</td><td align="center">96.76</td></tr><tr class="table-tr"><td colspan="7"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Chromatography Research International

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Table 4

Table 4: Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form 

Table 4 | Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form 