Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr class="thead"><td align="left" rowspan="2">Formulation</td><td align="center" colspan="3">Labelled amount (mg)</td><td align="center" colspan="3">                           % Recovery<sup>b</sup></td></tr><tr class="thead"><td align="center">CPM</td><td align="center">IBU</td><td align="center">PHE</td><td align="center">CPM</td><td align="center">IBU</td><td align="center">PHE</td></tr><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td align="left"> ADVIL allergy and congestive relief</td><td align="center">4</td><td align="center">200</td><td align="center">10</td><td align="center"><span style="width: 90.6875px;"><svg height="11.2875" id="M11" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 90.6875 11.2875" width="90.6875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>Mean value ± standard deviation of three determinations; tablet formulation, ADVIL allergy and congestion relief, Pfizer Pharmaceutical, Madison, USA containing labeled amount of 4 mg of chlorpheniramine maleate, 200 mg of ibuprofen, and 10 mg of phenylephrine hydrochloride.<br/></td></tr></table>

Chromatography Research International

tab5

Table 5

Table 5: Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form 

Table 5 | Development and Validation of an RP-HPLC Method for Estimation of Chlorpheniramine Maleate, Ibuprofen, and Phenylephrine Hydrochloride in Combined Pharmaceutical Dosage Form 