MMP inhibitor and actin polymerization inhibitor affect MDA-MB-231 collagen remodeling ability. MDA-MB-231 cells were cultured in collagen matrix and treated with Marimastat (MMP inhibitor) or Latrunculin B (actin polymerization inhibitor) for 4 consecutive days. Both treatments significantly compromised the collagen compaction ability of MDA-MB-231 cells. While the effect of Marimastat is milder, Latrunculin B treatment resulted in the compaction degree similar to collagen matrix with MCF-7 cells. * indicates the standard deviation is significantly different from the collagen matrix without cells ( by -test).