Research Article
Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives
Table 1
Antibacterial and anti-fungal activity of newly synthesized chalcone derivatives (2a–2e, 3a–3e) and pyrimidine derivatives (4a–4e, 5a–5e).
| Compound
(500 μg/disk) | Average value of zone of inhibition in mm | | Antimicrobial Activity | | | Gram Positive | Gram Negative | Antifungal activity | | S. aureus | B. subtilis | P. vulgaris | E. coli | C. albicans | A. niger |
| | 2a | — | — | — | — | — | — | | 2b | 10 | 08 | 13 | 12 | 11 | 13 | | 2c | 11 | 06 | 16 | 14 | 12 | 16 | | 2d | 6 | 8 | 10 | 08 | 08 | 10 | | 2e | — | 4 | — | — | — | — | | 3a | — | — | 5 | 4 | — | — | | 3b | 13 | 10 | 14 | 14 | 16 | 15 | | 3c | 12 | 13 | 16 | 15 | 17 | 18 | | 3d | 8 | 14 | 12 | 10 | 12 | 13 | | 3e | — | 5 | — | 4 | 5 | 4 | | 4a | 4 | 3 | 6 | 8 | 8 | 10 | | 4b | 14 | 13 | 17 | 14 | 16 | 17 | | 4c | 15 | 08 | 19 | 18 | 18 | 20 | | 4d | 10 | 12 | 12 | 14 | 16 | 20 | | 4e | 7 | 6 | 8 | 10 | 14 | 12 | | 5a | 5 | 6 | 9 | 8 | 12 | 14 | | 5b | 29 | 18 | 24 | 26 | 22 | 25 | | 5c | 22 | 24 | 26 | 24 | 20 | 27 | | 5d | 13 | 15 | 16 | 12 | 24 | 21 | | 5e | 12 | 10 | 15 | 16 | 16 | 15 | | Ciprofloxacin | 30 | 26 | 32 | 31 | — | — | | Fluconazole | — | — | — | — | 24 | 26 |
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“—” represent “inactive”.
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