Research Article

Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells

Table 3

Effects of DHMEQ on the radiosensitivity of GBM cell lines. Single cells were pretreated with 10 μg/mL for 24 h and irradiated with 2, 4, and 6 Gy. After 7 days survival fractions were calculated. Dose enhancement rate (DER) >1 denotes a supraadditive effect. § Colony formation capacity was completely abolished after combined treatment.

Cell line
U251U343MG-aU138MGU87MGT98GLN319

DHMEQ 10 μg/mL +2 Gy5.503.2917.000.953.004.73
4 Gy9.508.5016.361.302.504.47
6 Gy§8.001.331.353.753.47