Review Article

Postinfantile Giant Cell Hepatitis: An Etiological and Prognostic Perspective

Table 2

Cases of post infantile Giant hepatitis with their prognostic outcome.

EtiologyNumber of casesPrognostic outcome References

Drugs
 Methotrexate 2Good (mild hepatitis)[1, 5]
 Chlorpromazine 1Good (mild hepatitis)[1]
  ISABGOL1Good (mild hepatitis)[6]
 Clometacine1Poor (acute liver failure)[7]
 Amoxicillin and
 Clavulanate
1Poor (chronic hepatitis with acute decompensation)[8]
 Doxycycline1Poor (acute liver failure)
Treated for a week for bacterial bronchitis
[9]

Autoimmune
 AIH51 (died)
4 Good (clinically improved)
[1]
21 Moderate (rapid onset of cirrhosis died)
1 Moderate (rapid onset of cirrhosis)
[5]
10Moderate 25% (acute hepatitis), 42% moderate (chronic active hepatitis), 33% moderate to poor cirrhosis, >1-month duration[2]
 AIH134 Poor (liver failure)[7]
5 Moderate (rapid cirrhosis)
4 Good (responded to immunosuppressants)
1Moderate (rapid onset of cirrhosis)[10]
1Good (responded to immunossuppresion)[11]
 SLE2Moderate[2, 12]
 Autoimmune hemolytic
 anemia
3Poor[1315]
 PSC + AIH2Moderate (rapid onset of cirrhosis)
Good (mild hepatitis)
[16, 17]
 AIH + polyarthritis1Moderate (early cirrhosis)[18]
 AIH + polyarteritis1Moderate (early cirrhosis)[19]
 AIH + UC1Moderate (early cirrhosis)[20]
 PBC21 Poor, (liver failure) 1 moderate (early cirrhosis)[21, 22]
 AIH II1Poor (died)[23]

Viral
 HAV4Poor (fatal liver failure)[1, 2426]
 HEV1Good (mild hepatitis)[27]
 HBV3Good (1 acute hepatitis, 2 chronic hepatitis)[2, 7]
 HCV22Good (chronic hepatitis)[5, 2830]
 EBV3Poor (fatal liver failure)[3133]
 Paramyxoviruses13Poor (7 fatal liver failure, 6 died)[3, 26, 34, 35]
 HIV + HCV2Good (chronic hepatitis)[30]
 HIV2Good (chronic hepatitis)[36]
 HHV-6A1Good (chronic hepatitis)[27]
 CMV1Poor (acute liver failure with underlying Wilson’s diseases)[37]

Hypereosinophilia32 Poor (liver failure)
1 Good
[24, 32, 38]
CLL32 Poor (liver failure)
1 Good (responded to immunosuppression)
[39]
Posttransplant10Poor (recurrent disease, mostly required retransplant)[4043]