Comparison of the amino acid sequence of the VARV A36R protein with the corresponding VACV, CPXV, MPXV, and ECTV orthologs. Identical amino acids in the compared sequence of virus genomes relative to the VARV strain India-1967 are denoted with dots and deletions, with dashes. The amino acid positions in analyzed segment are shown above the amino acid sequence. Potential VARV antigenic determinants are underlined and framed. The strains VARV_IND, VARV_GAR, VARV_BSH, VACV_COP, VACV_WR, VACV_ANK, CPXV_BRT, CPXV_GRI, MPXV_ZAI, MPXV_USA, and ECTV_MOS have the following PubMed accession numbers: X69198, Y16780, L22579, M35027, AY243312, U94848, AF482758, X94355, AF380138, DQ011157, and AF012825. The ECTV_NAV amino acid sequence was taken from http://www.sanger.ac.uk/.