Chromatography Research International / 2013 / Article / Tab 5 / Research Article
Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form Table 5 Critical parameters extracted for method 1.
Critical parameters extracted By observation By principal component analysis Parameter Extracted result Parameter Extracted result Solvent Methanol Wavelength 250 nm Saturation time 20 min Band length 8 mm Mode of detection Absorbance Solvent front 70 mm Volume of mobile phase 5 mL Type of chamber 10 cm × 10 cm Plate Precoated plate Scanning time 10 min Mobile phase composition Methanol : ethyl acetate : triethylamine (1.5 : 3.5 : 0.4 v/v)