Research Article

Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form

Table 5

Critical parameters extracted for method 1.

Critical parameters extracted
By observationBy principal component analysis
ParameterExtracted resultParameterExtracted result

SolventMethanolWavelength250 nm
Saturation time20 min
Band length8 mm

Mode of detectionAbsorbanceSolvent front70 mm
Volume of mobile phase5 mL
Type of chamber10 cm × 10 cm

PlatePrecoated plateScanning time10 min
Mobile phase compositionMethanol : ethyl acetate : triethylamine (1.5 : 3.5 : 0.4 v/v)