Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form

<table class="table-group" id="tab6"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="center" colspan="4">Critical parameters extracted</td></tr><tr class="thead"><td align="center" colspan="2">By observation</td><td align="center" colspan="2">By principal component analysis</td></tr><tr class="thead"><td align="left">Parameter</td><td align="center">Extracted result</td><td align="center">Parameter</td><td align="center">Extracted result</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left" rowspan="2">Solvent</td><td align="center" rowspan="2">Methanol</td><td align="center">Wavelength</td><td align="center">247.4 nm</td></tr><tr><td align="center">Scan speed</td><td align="center">Medium</td></tr><tr><td align="left" rowspan="2">Sample preparation</td><td align="center" rowspan="2">Tablet</td><td align="center">Slit width</td><td align="center">1.0</td></tr><tr><td align="center">Sampling interval</td><td align="center">0.2</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Critical parameters extracted for method 2.

Chromatography Research International

tab6

Table 6

Table 6: Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form 

Table 6 | Implementation of QbD Approach to the Analytical Method Development and Validation for the Estimation of Propafenone Hydrochloride in Tablet Dosage Form 