Alterations of Hormone-Sensitive Adenylyl Cyclase System in the Tissues of Rats with Long-Term Streptozotocin Diabetes and the Influence of Intranasal Insulin
Figure 1
The stimulating effects of (a) GppNHp and (b) forskolin on the basal AC activity in the heart, brain, and testes in diabetic and control rats treated with I-I or saline. C: control animals; CI: control animals treated with intranasal insulin (I-I); D: diabetic animals with 210-day streptozotocin-induced diabetes mellitus of the type 1 (T1DM); DI: diabetic animals treated with I-I. GppNHp and forskolin were taken at M. Values are the weighted mean ± weighted standard deviation of three individual experiments, each performed in triplicate. * and *** denote the statistically significant difference between Groups C and D at and 0.001; ###, the same between Groups D and DI at ; &, &&, and &&&, the same between Groups CI and DI at , 0.01, and 0.001, respectively.
