Chromatography Research International

Research Article

A New Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Pyridoxine Hydrochloride and Meclizine Hydrochloride in Pharmaceutical Solid Dosage Forms

Table 3

Results showing different degradative outcomes.
ParametersPyrimac tablet (mg tab−1)Assay at forced condition (mg tab−1)*Percent of degradation (%)
PYHMEHPYHMEHPYHMEH
Normal50.0025.00    
Acidic  49.39 ± 0.1023.84 ± 0.091.224.64
Alkaline  49.40 ± 0.0823.75 ± 0.111.205.00
Oxidation  48.11 ± 0.0623.85 ± 0.073.784.60
Reduction  49.68 ± 0.1223.90 ± 0.150.644.40
Mean of three replicate, tab: Tablet.