Research Article
Longitudinal Imaging of Cancer Cell Metastases in Two Preclinical Models: A Correlation of Noninvasive Imaging to Histopathology
Table 1
Summary of melanoma cancer cell metastases detected by histopathology and [18F]FDG-PET.
| | | | Mouse number | | Tissues with melanoma cancer cell metastasis | Method of detection | 1 | 2 | 3 | 4 | 5 |
| | Lung | [18F]FDG-PET | + | + | + | + | + | | Histopathology | + | + | + | + | + | | Mediastinum | [18F]FDG-PET | − | − | − | − | − | | Histopathology | + | − | − | − | + | | Mediastinal lymph node | [18F]FDG-PET | − | − | − | − | − | | Histopathology | − | − | + | + | − | | Kidney* | [18F]FDG-PET | + | + | + | + | + | | Histopathology | − | + | − | − | + | | Mesentery | [18F]FDG-PET | − | − | − | − | − | | Histopathology | − | − | − | − | + | | Percentage of lung section involved in melanoma cancer cell metastasis | | 40.3 | 13.2 | 32.0 | 66.2 | 60.6 | | Percent injected dose of [18F]FDG in the lung | | 0.35 | 0.19 | 0.49 | 0.78 | 0.69 |
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+: metastasis; −: no metastasis; *[18F]FDG-PET is cleared primarily through kidney and may not be a true reflection of presence of metastasis.
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