Research Article
Longitudinal Imaging of Cancer Cell Metastases in Two Preclinical Models: A Correlation of Noninvasive Imaging to Histopathology
Table 2
Comparison of organs with tumor lesions detected by histopathology between the two metastatic models.
| | Organs | Experimental metastasis (tail-vein injection) | Spontaneous metastasis (mammary fat pad injection) | | B16-F10 | 4T1 (primary tumor resected) | 4T1 (primary tumor intact) |
| | Lung | 10/10 (100%) | 5/5 (100%) | 5/5 (100%) | | Mediastinal lymph node | 4/10 (40%) | — | — | | Mediastinum | 5/10 (50%) | 2/5 (40%) | 3/5 (60%) | | Vertebra/spinal cord | 2/10 (20%) | — | 1/5 (20%) | | Brain | — | — | 2/5 (40%) | | Kidney | 2/10 (20%) | — | 1/5 (20%) | | Liver | — | — | 2/5 (40%) | | Thymus | — | 2/5 (40%) | 2/5 (40%) | | Rib | — | 2/5 (40%) | — | | Adrenal | — | 1/5 (20%) | 4/5 (80%) | | Heart | — | — | 1/5 (20%) | | Mesentery | 1/10 (10%) | — | — | | Subcutaneous lymph node | — | 2/5 (40%) | 1/5 (20%) | | Sternum and foreleg | — | — | 1/5 (20%) |
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