KCNQ1 within the human KCNQ subunit gene family. Clustal alignment of all five KCNQ (Kv7) subfamily members showing the selectivity filter (SF, shaded yellow) and surrounding residues, to illustrate sequence differences (red letters) between KCNQ1 (Kv.1) and other family members. Black asterisks, conserved residues; red asterisks, residues conserved in all KCNQ family members except KCNQ1; Numbers, human KCNQ1 protein sequence numbering. Order of sequences was automatically determined by sequence similarity within Clustal.