Architecture of the MYC family. The image at the top shows a generic representation of a mammalian MYC protein, indicating the transcriptional activation domain, the central portion, the canonical nuclear localization sequence (N), and the region involved in DNA binding via interaction with MAX. Below is a representation of conserved sequences present in C-, N-, and L-MYC family members. c-MYC is drawn to scale at 439 amino acids. N- and L-MYC proteins are different lengths (464 and 364 amino acids, resp.) due to differences in the length of nonconserved sequences but are drawn to highlight the conservation and relative location of Myc boxes.