Review Article
The Biosynthesis of the Molybdenum Cofactor in Escherichia coli and Its Connection to FeS Cluster Assembly and the Thiolation of tRNA
Table 1
Overview on the E. coli molybdoenzymes and the involved chaperones required for maturation/cofactor insertion.
| | Mo-enzyme | Subunits | Chaperone | Moco |
| | DMSO reductase family | | | | | Nitrate reductase A | NarGHI | NarJ | bis-MGD | | Nitrate reductase Z | NarZYV | NarW | bis-MGD | | Peripl. nitrate reductase | NapABCGH | NapD | bis-MGD | | TMAO reductase A | TorAC | TorD | bis-MGD | | TMAO reductase Z | TorZY | ? | bis-MGD | | DMSO reductase | DmsABC | DmsD | bis-MGD | | Formate dehydrogenase N | FdnGHI | FdhD | bis-MGD | | Formate dehydrogenase O | FdoGHI | FdhD | bis-MGD | | Formate dehydrogenase H | FdhF | FdhD | bis-MGD | | Biotin sulfoxide reductase | BisC | — | bis-MGD | | Selenate reductase | YnfEFGH | DmsD | bis-MGD | | ? | YdhYVWXUT | ? | ? | | ? | YdeP | ? | ? | | Xanthine oxidase family | | | | | Aldehyde oxidoreductase | PaoABC | PaoD | MCD | | Xanthine dehydrogenase | XdhABC | YqeB | MCD | | ? | XdhD (YgfM) | YqeB | ? | | Sulfite oxidase family | | | | | Sulfite oxidase | YedYZ | — | Mo-MPT | | ? | YcbX | — | ? | | ? | YiiM | — | ? |
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—: no chaperone identified.
?: function unknown or not clear which chaperone is involved in maturation, form of Moco not characterized.
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