Review Article
Advances in Microelectronics for Implantable Medical Devices
Table 1
Comparison of integrated neural amplifiers.
| Parameter | [34] | [109] | [45] | [110] | [111] | [112] | [29] | [42] | [35] | [37] | [44] | [40] | [39] | [46] | [36] |
| Year | 2003 | 2004 | 2007 | 2009 | 2009 | 2010 | 2010 | 2011 | 2012 | 2012 | 2013 | 2013 | 2013 | 2013 | 2013 |
| Fully differential | No | No | No | No | Yes | Yes | Yes | No | Yes | Yes | No | No | No | No | Yes |
| CMOS process (m) | 0.5 | 1.5 | 0.18 | 0.35 | 0.13 | 0.35 | 0.18 | 0.18 | 0.13 | 0.13 | 0.35 | 0.18 | 0.18 | 0.18 | 0.18 |
| Area (mm2) | 0.16 | 0.107 | 0.05 | N/A | N/A | 0.02 | N/A | 0.063 | 0.054 | 0.072 | 0.065 | 0.065 | N/A | 0.76 | 0.16 |
| Supply voltage (V) | 5 | 3 | 1.8 | 1 | 1 | 3 | 1.6 | 1.8 | 1.2 | 1 | 3 | 1.8 | 1/1.8 | 1 | 1.2 |
| Supply current (A) | 16 | 38.27 | 4.67 | 1.26 | 12.5 | 2.8 | 43.12 | 4.4 | 1.6 | 12.1 | 2 | 6.1 | 1.2 | 13 | 0.36 |
| Gain (dB) | 39.5 | 39.3 | 49.52 | 45.7 | 38.3 | 33 | 19.1/37.5 | 39.4 | 47.5 | 40 | 37.5 | 48/60 | 54.8/60.9 | 44.5/55.9 | 26 |
| Bandwidth (Hz) | 25 m–7.2 k | 0–9.1 k | 98.4–9.1 k | 0.23–7.8 k | 23 m–11.5 k | 10–5 k | 100–8 k | 10–7.2 k | 167–6.9 k | 50 m–10.5 k | 1–10 k | 0.3–9 k | 0.38–5.1 k | 1–10 k | 80–15 k |
| Input-referred noise () | 2.2 | 7.8 | 5.6 | 4.43 | 1.95 | 6.08 | 2.36 | 3.5 | 3.8 | 2.2 | 10.6 | 5 | 4 | 4.4* | 8.1 | Noise bandwidth (Hz) | N/A | 0.1–10 k | 1–9.1 k | 1–12 k | 0.1–25.6 k | 10–5 k | 1–8 k | 10–100 k | 1–100 k | 0.1–105 k | 1–10 k | 1–8 k | 1–8 k | 0.3–10 k | N/A |
| CMRR (dB) | ≥83 | N/A | 52.68 | 58 | >63 | 60 | 79 | 70.1 | 83 | 80 | 74 | 48 | >60 | N/A | >60 |
| PSRR (dB) | ≥85 | N/A | 51.93 | 40 | >63 | N/A | 62 | 63.8 | 70 | ≥80 | 55 | 55 | >70 | N/A | >80 |
| THD Input range (mVpp) | 1% 16.7 | 1.1% 5 | 1% 2.4 | 0.53% 5.2 | 1% 1 | N/A | N/A | 1% 5.7 | 1% 3.1 | 1% 1 | 1% 2.4 | 1.2 1 | 1% 1.63 | 1.03 ** | 0.05% 10 |
| NEF | 4 | 19.4 | 4.9 | 2.16 | 2.48 | 5.55 | 6.68 | 3.35 | 2.16 | 2.9 | 5.78 | 4.6 | 1.9 | 5.45 | 1.52 |
| | 80 | 1129 | 43.22 | 4.53 | 6.15 | 92.41 | 71.39 | 20.20 | 5.59 | 8.41 | 100.22 | 38.08 | 3.61 | 29.7 | 2.77 |
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Referred to the input node of the electrode.
**The amplitude range of the input current is 20 nApp.
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