Abstract
We first introduce a generalization of the Bernoulli polynomials, and consequently of the Bernoulli numbers, starting from suitable generating functions related to a class of Mittag-Leffler functions. Furthermore, multidimensional extensions of the Bernoulli and Appell polynomials are derived generalizing the relevant generating functions, and using the Hermite-Kampé de Fériet (or Gould-Hopper) polynomials. The main properties of these polynomial sets are shown. In particular, the differential equations can be constructed by means of the factorization method.