Recurrence Quantification Analysis of Spontaneous Electrophysiological Activity during Development: Characterization of In Vitro Neuronal Networks Cultured on Multi Electrode Array Chips
Figure 3
Mean Burst Rate, mean Burst Duration (weighed value), mean Interburst Interval, and the weighted mean Interburst Interval. Bursting behavior starts being recordable after the second week in vitro. Until the third week, bursts are generated at low frequency and low amplitude (i.e., the number of spikes belonging to the same burst). The mean burst duration shows less variation during network development. The weighted burst duration shows that the network is most active during the third week. The mean interburst interval (at channel level) is variable, while the weighted interburst interval (interburst interval/number of active bursting channels) shows the lowest values during the third week and confirms that the rate of burst event is higher in this period.
