Table of Contents
Advances in Anesthesiology
Volume 2015, Article ID 708915, 6 pages
Research Article

Effect of Low and High Dose Sugammadex on the Coagulation and Fibrinolytic System in Rats

1Department of Anesthesiology, Faculty of Medicine, Ordu University, 52100 Ordu, Turkey
2Department of Biochemistry, Faculty of Medicine, Ordu University, 52100 Ordu, Turkey
3Department of Anesthesiology, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey
4Department of Biochemistry, Ordu State Hospital, 52100 Ordu, Turkey

Received 19 April 2015; Accepted 25 May 2015

Academic Editor: Ming-Hwang Shyr

Copyright © 2015 Nilay Taş et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Sugammadex is a new reversal agent that has entered use recently. It is known that with sugammadex some changes in coagulation parameters occur without documented clinical results. Aim of the Work. The objective of this study was to identify effects of sugammadex on liver functions, coagulation, and fibrinolytic systems. Methods. Thirty-six rats were randomized into six groups: Group I, control; Group II, rocuronium group; Group III, sugammadex administered in 16 mg kg−1 dose; Group IV, sugammadex administered in 96 mg kg−1 dose; Group V, rocuronium and sugammadex administered in 16 mg kg−1 dose; and Group VI, rocuronium and sugammadex administered in 96 mg kg−1 dose. After 120 minutes, blood samples were obtained for prothrombin time, activated partial thromboplastin time, D-dimer, fibrinogen, aspartate aminotransferase, alanine aminotransferase, albumin, platelet, and mean platelet volume analyses. Results. Compared to the control group, in all groups measured parameters did not show any effect from a statistical viewpoint either due to the administered drugs alone or due to interaction effects. Conclusion. The conclusion was reached that administration of sugammadex in rats did not have any significant effect on the fibrinolytic system, coagulation parameters, and liver function.