The Role of the Actin Cytoskeleton and Lipid Rafts in the Localization and Function of the ABCC1 Transporter
Figure 1
Metabolism of sphingolipids (a) and cholesterol (b) and the steps where the indicated inhibitors act. ISP-1 acts on the first step of sphingolipid metabolism, that is, the condensation of serine and palmitoyl-CoA. Both NB-dNJ and t-PPPP inhibit the conversion of ceramide into glucosylceramide by glucosylceramide synthase (a). Cholesterol biosynthesis is inhibited by statins, such as lovastatin, which act on an early step in the pathway by inhibiting HMG-CoA reductase. RO48-8071 inhibits a late step in the pathway, that is, formation of lanosterol by lanosterol synthase, which is an oxidosqualene cyclase enzyme (b).
