Illustration showing the process of neurulation. The ectoderm (yellow) gives rise to the neural plate in the midline and future epidermis at its lateral edges. Between epidermis and neural plate lies the neural plate border that contains presumptive neural crest cells (red). As the neural plate invaginates to form the neural tube, the neural folds (red) elevate, eventually fusing such that presumptive neural crest cells lie in the dorsal portion of the closed neural tube. Finally, they undergo epithelial to mesenchymal transition, leaving the neural tube and migrating into the periphery.
