Table of Contents
Advances in Biology
Volume 2014 (2014), Article ID 837891, 13 pages
http://dx.doi.org/10.1155/2014/837891
Review Article

Colorful World of Microbes: Carotenoids and Their Applications

1Department of Bioscience and Biotechnology, Banasthali University, Jaipur, Rajasthan 304022, India
2Biotechnology Division, Defence Research and Development Establishment, Gwalior, Madhya Pradesh 474012, India
3Biochemical Engineering Department, BT Kumaon Institute of Technology, Dwarahat, Uttarakhand 263653, India

Received 26 January 2014; Revised 2 March 2014; Accepted 4 March 2014; Published 13 April 2014

Academic Editor: Akikazu Sakudo

Copyright © 2014 Kushwaha Kirti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Pattnaik, U. Roy, and P. Jain, “Biocolours: new generation additives for food,” Indian Food Industry, vol. 16, no. 5, pp. 21–32, 1997. View at Google Scholar
  2. H. J. Nelis and A. P. de Leenheer, “Microbial sources of carotenoid pigments used in foods and feeds,” Journal of Applied Bacteriology, vol. 70, no. 3, pp. 181–191, 1991. View at Google Scholar · View at Scopus
  3. L. Dufosse, “Pigments,” Encyclopedia of Microbiology, vol. 4, pp. 457–471, 2009. View at Google Scholar
  4. S. Babu and I. S. Shenolikar, “Health and nutritional implications of food colours,” Indian Journal of Medical Research, vol. 102, pp. 245–249, 1995. View at Google Scholar · View at Scopus
  5. E. A. Johnson and W. A. Schroeder, “Microbial carotenoids,” Advances in biochemical engineering/biotechnology, vol. 53, pp. 119–178, 1996. View at Google Scholar · View at Scopus
  6. V. R. O. Canizares, L. E. Rios, R. R. Olvera, N. T. Ponce, and R. F. Marquez, “Microbial sources of pigments,” Revista Latinoamericana de Microbiología, vol. 40, no. 1-2, pp. 87–107, 1998. View at Google Scholar
  7. S. Babitha, Biotechnology for Agro-Industrial. Residues Utilization II, Microbial Pigments, 2009.
  8. V. K. Joshi, D. Attri, A. Bala, and S. Bhushan, “Microbial pigments,” Indian Journal of Biotechnology, vol. 2, no. 3, pp. 362–369, 2003. View at Google Scholar · View at Scopus
  9. H. Klaui, “Industrial and commercial uses of carotenoids,” in IUPAC Carotenoid Chemistry and BioChemistry, G. Britton and T. W. Goodwin, Eds., pp. 309–317, Pergamon Press, Oxford, UK, 1982. View at Google Scholar
  10. I. H. Ciapara, L. F. Valenzuela, F. M. Goycoolea, and W. A. Monal, “Microencapsulation of astaxanthin in a chitosan matrix,” Carbohydrate Polymers, vol. 56, no. 1, pp. 41–45, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Saha, R. Thavasi, and S. Jayalakshmi, “Phenazine pigments from Pseudomonas aeruginosa and their application as antibacterial agent and food colourants,” Research Journal of Microbiology, vol. 3, no. 3, pp. 122–128, 2008. View at Google Scholar · View at Scopus
  12. S. Alcantara and S. Sanchez, “Influence of carbon and nitrogen sources on Flavobacterium growth and zeaxanthin biosynthesis,” Journal of Industrial Microbiology and Biotechnology, vol. 23, no. 1, pp. 697–700, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Lorquin, F. Molouba, and B. L. Dreyfus, “Identification of the carotenoid pigment canthaxanthin from photosynthetic Bradyrhizobium strains,” Applied and Environmental Microbiology, vol. 63, no. 3, pp. 1151–1154, 1997. View at Google Scholar · View at Scopus
  14. A. Yokoyama, H. Izumida, and W. Miki, “Production of astaxanthin and 4-ketozeaxanthin by the marine bacterium, Agrobacterium aurantiacum,” Bioscience, Biotechnology and Biochemistry, vol. 58, no. 10, pp. 1842–1844, 1994. View at Google Scholar · View at Scopus
  15. A. Tsubokura, H. Yoneda, and H. Mizuta, “Paracoccus carotinifaciens sp. nov., a new aerobic Gram-negative astaxanthin-producing bacterium,” International Journal of Systematic Bacteriology, vol. 49, no. 1, pp. 277–282, 1999. View at Google Scholar · View at Scopus
  16. M. Hümbelin, A. Thomas, J. Lin, J. Li, J. Jore, and A. Berry, “Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens,” Gene, vol. 297, no. 1-2, pp. 129–139, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. H. C. Zhang, J. X. Zhan, K. M. Su, and Y. X. Zhang, “A kind of potential food additive produced by Streptomyces coelicolor: characteristics of blue pigment and identification of a novel compound, λ-actinorhodin,” Food Chemistry, vol. 95, no. 2, pp. 186–192, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Y. Liu and V. Nizet, “Color me bad: microbial pigments as virulence factors,” Trends in Microbiology, vol. 17, no. 9, pp. 406–413, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Britton, “Structure and properties of carotenoids in relation to function,” The FASEB Journal, vol. 9, no. 15, pp. 1551–1558, 1995. View at Google Scholar · View at Scopus
  20. “IUPAC commission on the nomenclature of organic chemistry and IUPAC-IUB commission on biochemical nomenclature, nomenclature of carotenoids (Rules approved 1974),” Pure and Applied Chemistry, vol. 41, pp. 407–431, 1975.
  21. A. Wisniewska and W. K. Subczynski, “Effects of polar carotenoids on the shape of the hydrophobic barrier of phospholipid bilayers,” Biochimica et Biophysica Acta, vol. 1368, no. 2, pp. 235–246, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. M. G. Simic, “Carotenoid free radicals,” Methods in Enzymology, vol. 213, pp. 444–453, 1992. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Fuciman, P. Chabera, A. Zupcanova et al., “Excited state properties of aryl Carotenoids,” Physical Chemistry Chemical Physics, vol. 12, no. 3, pp. 3112–3120, 2010. View at Google Scholar
  24. A. Vershinin, “Biological functions of Carotenoids—diversity and evolution,” BioFactors, vol. 10, no. 2-3, pp. 99–104, 1999. View at Google Scholar · View at Scopus
  25. H. A. Frank and R. J. Cogdell, “The photochemistry and functions of carotenoids in photosynthesis,” in Carotenoids in Photosynthesis, A. Young and G. Britton, Eds., pp. 252–326, Springer, London, UK, 1993. View at Google Scholar
  26. M. M. Mathews-Roth, “Medical application and uses of Carotenoids,” in Carotenoid-Chemistry and Boichemistry IUPAC, G. Britton and T. W. Goodwin, Eds., pp. 297–307, Pergamon Press, Oxford, UK, 1982. View at Google Scholar
  27. W. I. Gruszecki and K. Strzałka, “Carotenoids as modulators of lipid membrane physical properties,” Biochimica et Biophysica Acta, vol. 1740, no. 2, pp. 108–115, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. J. A. Olson and N. I. Krinsky, “Introduction: the colorful, fascinating world of the carotenoids: important physiologic modulators,” The FASEB Journal, vol. 9, no. 15, pp. 1547–1550, 1995. View at Google Scholar · View at Scopus
  29. G. Britton, “UV/Visible spectroscopy,” in Spectroscopy 1B, G. Britton, J. S. Liaanen, and H. Pfander, Eds., pp. 13–62, Birkhäuser, Basel, Switzerland, 1995. View at Google Scholar
  30. W. I. Gruszecki and J. Sielewiesiuk, “Orientation of xanthophylls in phosphatidylcholine multibilayers,” Biochimica et Biophysica Acta, vol. 1023, no. 3, pp. 405–412, 1990. View at Publisher · View at Google Scholar · View at Scopus
  31. G. A. Armstrong, “Genetics of eubacterial carotenoid biosynthesis: a colorful tale,” Annual Review of Microbiology, vol. 51, pp. 629–659, 1997. View at Publisher · View at Google Scholar · View at Scopus
  32. N. J. C. Fong, M. L. Burgess, K. D. Barrow, and D. R. Glenn, “Carotenoid accumulation in the psychrotrophic bacterium Arthrobacter agilis in response to thermal and salt stress,” Applied Microbiology and Biotechnology, vol. 56, no. 5-6, pp. 750–756, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Ourisson and Y. Nakatani, “Bacterial Carotenoids as membrane reinforcers: a general role of polyterpenoids: membrane stabilization,” in Carotenoids: Chemistry and Biochemistry, N. I. Krinsky, M. M. Mathew-Roth, and R. F. Taylor, Eds., pp. 237–245, Plenum Press, New York, NY, USA, 1989. View at Google Scholar
  34. S. Rottem and O. Markowitz, “Carotenoids act as reinforcers of the Acholeplasma laidlawii lipid bilayer,” Journal of Bacteriology, vol. 140, no. 3, pp. 944–948, 1979. View at Google Scholar · View at Scopus
  35. M. V. Jagannadham, K. Narayanan, C. Mohan Rao, and S. Shivaji, “In vivo characteristics and localisation of carotenoid pigments in psychrotrophic and mesophilic Micrococcus roseus using photoacoustic spectroscopy,” Biochemical and Biophysical Research Communications, vol. 227, no. 1, pp. 221–226, 1996. View at Publisher · View at Google Scholar · View at Scopus
  36. V. V. Petrunyaka, “Localization and role of carotenoids in molluscan neurons,” Cellular and Molecular Neurobiology, vol. 2, no. 1, pp. 11–20, 1982. View at Google Scholar · View at Scopus
  37. R. J. Cogdell, P. Fyfe, N. Fraser et al., “Photosynthetic light harvesting,” in Microbial Responses to Light and Time, M. X. Caddick, S. Baumberg, D. A. Hodgson, and M. K. Phillips Jones, Eds., pp. 143–158, SGM symposium, Cambridge University Press, Cambridge, UK, 1998. View at Google Scholar
  38. H. Wackerbarth, T. Stoll, S. Gebken, C. Pelters, and U. Bindrich, “Carotenoid-protein interaction as an approach for the formulation of functional food emulsions,” Food Research International, vol. 42, no. 9, pp. 1254–1258, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. L. P. Vernon and F. G. Augusto, “Pigment protein complexes derived from Rhodospirillum rubrum chromatophores by enzymatic digestion,” Biochimica et Biophysica Acta, vol. 143, no. 1, pp. 144–153, 2003. View at Google Scholar
  40. report code: FOD025C, 2008http://www.bccresearch.com/report/FOD025C.html.
  41. G. A. Armstrong, “Eubacteria show their true colors: genetics of carotenoid pigment biosynthesis from microbes to plants,” Journal of Bacteriology, vol. 176, no. 16, pp. 4795–4802, 1994. View at Google Scholar · View at Scopus
  42. S. Pandian, S. Saengchjan, and T. S. Raman, “An alternative pathway for the biosynthesis of isoprenoid compounds in bacteria,” Biochemical Journal, vol. 196, no. 3, pp. 675–681, 1981. View at Google Scholar · View at Scopus
  43. M. S. Anderson, J. G. Yarger, C. L. Burck, and C. D. Poulter, “Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae,” Journal of Biological Chemistry, vol. 264, no. 32, pp. 19176–19184, 1989. View at Google Scholar · View at Scopus
  44. Y. Tani, “Microbial production of vitamin B6 and derivatives,” in Biotechnology of Vitamins, Pigments and Growth Factors, E. J. Vandamme, Ed., pp. 221–230, Elsevier, London, UK, 1989. View at Google Scholar
  45. S. Fujisaki, H. Hara, Y. Nishimura, K. Horiuchi, and T. Nishino, “Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli,” Journal of Biochemistry, vol. 108, no. 6, pp. 995–1000, 1990. View at Google Scholar · View at Scopus
  46. J. Schwender, M. Seemann, H. K. Lichtenthaler, and M. Rohmer, “Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus,” Biochemical Journal, vol. 316, no. 1, pp. 73–80, 1996. View at Google Scholar · View at Scopus
  47. D. Umeno, A. V. Tobias, and F. H. Arnold, “Diversifying carotenoid biosynthetic pathways by directed evolution,” Microbiology and Molecular Biology Reviews, vol. 69, no. 1, pp. 51–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Liang, F. Zhao, W. Wei, Z. Wen, and S. Qin, “Carotenoid biosynthesis in cyanobacteria: structural and evolutionary scenarios based on comparative genomics,” International Journal of Biological Sciences, vol. 2, no. 4, pp. 197–207, 2006. View at Google Scholar · View at Scopus
  49. N. A. Moran and T. Jarvik, “Lateral transfer of genes from fungi underlies carotenoid production in aphids,” Science, vol. 328, no. 5978, pp. 624–627, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. W. F. Vincent, M. T. Downes, R. W. Castenholz, and C. Howard-Williams, “Community structure and pigment organisation of cyanobacteria-dominated microbial mats in Antarctica,” European Journal of Phycology, vol. 28, no. 4, pp. 213–221, 1993. View at Google Scholar · View at Scopus
  51. W. F. Vincent, D. R. Mueller, and S. Bonilla, “Ecosystems on ice: the microbial ecology of Markham Ice Shelf in the high Arctic,” Cryobiology, vol. 48, no. 2, pp. 108–112, 2004. View at Publisher · View at Google Scholar · View at Scopus
  52. K. Sabbe, D. A. Hodgson, E. Verleyen et al., “Salinity, depth and the structure and composition of microbial mats in continental Antarctic lakes,” Freshwater Biology, vol. 49, no. 3, pp. 296–319, 2004. View at Publisher · View at Google Scholar · View at Scopus
  53. D. R. Mueller, W. F. Vincent, S. Bonilla, and I. Laurion, “Extremotrophs, extremophiles and broadband pigmentation strategies in a high arctic ice shelf ecosystem,” FEMS Microbiology Ecology, vol. 53, no. 1, pp. 73–87, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. A. Oren and F. Rodriguez-Valera, “The contribution of halophilic Bacteria to the red coloration of saltern crystallizer ponds,” FEMS Microbiology Ecology, vol. 36, no. 2-3, pp. 123–130, 2001. View at Publisher · View at Google Scholar · View at Scopus
  55. J. F. Martin, E. Gudina, and J. Barredo, “Conversion of β-carotene into astaxanthin: two separate enzymes or a bifunctional hydroxylase-ketolase protein,” Microbial Cell Factories, vol. 7, no. 3, pp. 1475–2859, 2008. View at Google Scholar
  56. P. R. G. Schindler and H. Metz, “Bacteria of the Flexibacter Sporocytophaga group and violet-colored bacteria as indicators of hygienic hazardous drinking water,” Zentralblatt fur Hygiene und Umweltmedizin, vol. 189, no. 1, pp. 29–36, 1989. View at Google Scholar · View at Scopus
  57. J.-D. Gu and K. H. Cheung, “Phenotypic expression of Vogesella indigofera upon exposure to hexavalent chromium, Cr6+,” World Journal of Microbiology and Biotechnology, vol. 17, no. 5, pp. 475–480, 2001. View at Publisher · View at Google Scholar · View at Scopus
  58. Z. Vanessa and C. Cardona, Molecular analysis, physiological study and biotechnological capabilities of blue pigmented bacteria from Puerto Rico [Ph.D. dissertation], University of Puerto Rico, 2010.
  59. C. Nianhong, T. S. Bianchi, B. A. McKee, and J. M. Bland, “Historical trends of hypoxia on the Louisiana shelf: application of pigment as biomarkers,” Organic Geochemistry, vol. 32, no. 4, pp. 543–561, 2001. View at Google Scholar
  60. E. J. Vandamme, “Biotechnology of Vitamins, Pigments of growth factors,” in Applied Sciences, E. J. Vandamme, Ed., pp. 15–21, Elsevier Science Publishers, London, UK, 1989. View at Google Scholar
  61. A. Zeb and S. Mehmood, “Carotenoids content from various sources and their potential health applications,” Pakistan Journal of Nutrition, vol. 3, no. 3, pp. 199–204, 2004. View at Google Scholar
  62. C. C. Maramag, J. D. Ribaya-Mercado, P. Rayco-Solon et al., “Influence of carotene-rich vegetable meals on the prevalence of anaemia and iron deficiency in Filipino school children,” European Journal of Clinical Nutrition, vol. 64, no. 5, pp. 468–474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  63. A. Kornhauser, W. Wamer, and L. Lambert, in Carotenoids: Chemistry and Biology, N. I. Krinsky, M. M. Mathews-Roth, and R. F. Taylor, Eds., pp. 301–312, Plenum Press, New York, NY, USA, 1990.
  64. K. Ibrahim, T. J. Hassan, and S. N. Jafarey, “Plasma vitamin A and carotene in maternal and cord blood,” Asia-Oceania Journal of Obstetrics and Gynaecology, vol. 17, no. 2, pp. 159–164, 1991. View at Google Scholar · View at Scopus
  65. S. Patton, L. M. Canfield, G. E. Huston, A. M. Ferris, and R. G. Jensen, “Carotenoids of human colostrum,” Lipids, vol. 25, no. 3, pp. 159–165, 1990. View at Google Scholar · View at Scopus
  66. A. V. Rao and L. G. Rao, “Carotenoids and human health,” Pharmacological Research, vol. 55, no. 3, pp. 207–216, 2007. View at Publisher · View at Google Scholar · View at Scopus
  67. P. Di Mascio, S. Kaiser, and H. Sies, “Lycopene as the most efficient biological carotenoid singlet oxygen quencher,” Archives of Biochemistry and Biophysics, vol. 274, no. 2, pp. 532–538, 1989. View at Google Scholar · View at Scopus
  68. D. M. Snodderly, “Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins,” American Journal of Clinical Nutrition, vol. 62, no. 6, pp. 1448S–14615S, 1995. View at Google Scholar · View at Scopus
  69. M. G. Sajilata, R. S. Singhal, and M. Y. Kamat, “The carotenoid pigment zeaxanthin—a review,” Comprehensive Reviews in Food Science and Food Safety, vol. 7, no. 1, pp. 29–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  70. P. Bhosale, “Environmental and cultural stimulants in the production of carotenoids from microorganisms,” Applied Microbiology and Biotechnology, vol. 63, no. 4, pp. 351–361, 2004. View at Publisher · View at Google Scholar · View at Scopus
  71. H. McNulty, R. F. Jacob, and R. P. Mason, “Biological activity of Carotenoids related to distinct membrane physiochemical interactions,” American Journal of Cardiology, vol. 101, no. 10, pp. 20D–29D, 2008. View at Publisher · View at Google Scholar · View at Scopus
  72. A. Bendich, “Carotenoids and the immune response,” Journal of Nutrition, vol. 119, no. 1, pp. 112–115, 1989. View at Google Scholar · View at Scopus
  73. M. M. Mathews-Roth, “Plasma concentrations of carotenoids after large doses of β-carotene,” American Journal of Clinical Nutrition, vol. 52, no. 3, pp. 500–501, 1990. View at Google Scholar · View at Scopus
  74. H. Nishino, “Cancer prevention by carotenoids,” Mutation Research, vol. 402, no. 1-2, pp. 159–163, 1998. View at Publisher · View at Google Scholar · View at Scopus
  75. S. Agarwal and A. V. Rao, “Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study,” Lipids, vol. 33, no. 10, pp. 981–984, 1998. View at Google Scholar · View at Scopus
  76. N. V. Raj, D. Dhanashekaran, T. Nooruddin, and A. Panneerselvam, “Production of prodigiosin from Serratia marescens and its cytotoxicity activity,” Journal of Pharmacy Research, vol. 2, no. 4, pp. 590–593, 2009. View at Google Scholar
  77. C. Campàs, M. Dalmau, B. Montaner et al., “Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia,” Leukemia, vol. 17, no. 4, pp. 746–750, 2003. View at Publisher · View at Google Scholar · View at Scopus
  78. B. Montaner, S. Navarro, M. Piqué et al., “Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines,” British Journal of Pharmacology, vol. 131, no. 3, pp. 585–593, 2000. View at Google Scholar · View at Scopus
  79. E. Llagostera, V. Soto-Cerrato, R. Joshi, B. Montaner, P. Gimenez-Bonafé, and R. Pérez-Tomás, “High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation,” Anti-Cancer Drugs, vol. 16, no. 4, pp. 393–399, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. S. Nobutaka, N. Masami, H. Kazayuki, H. Tadaaki, and M. Katsumi, “Synergistic antifungal activity of chitinolytic enzymes and prodigiosin produced by biocontrol bacterium: serratia marescens strain B2 against gray mold pathogen: Botyritis cinerea,” Journal of General Plant Pathology, vol. 67, no. 4, pp. 312–319, 2001. View at Google Scholar
  81. R. A. Manderville, “Synthesis, proton-affinity and anti-cancer properties of the prodigiosin-group natural products,” Current Medicinal Chemistry-Anti-Cancer Agents, vol. 1, no. 2, pp. 195–218, 2001. View at Google Scholar · View at Scopus
  82. A. V. Giri, N. Anandkumar, G. Muthukumaran, and G. Pennathur, “A novel medium for the enhanced cell growth and production of prodigiosin from Serratia marcescens isolated from soil,” BMC Microbiology, vol. 4, pp. 1–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
  83. D. K. Paruchuri and R. M. Harshey, “Flagellar variation in Serratia marcescens is associated with color variation,” Journal of Bacteriology, vol. 169, no. 1, pp. 61–65, 1987. View at Google Scholar · View at Scopus
  84. Q.-J. Lu, C.-Y. Huang, S.-X. Yao, R.-S. Wang, and W. U. Xiao-Na, “Effects of fat soluble extracts from vegetable powder and beta-carotene on proliferation and apoptosis of lung cancer cell. YTMLC-90,” Biomedical and Environmental Sciences, vol. 16, no. 3, pp. 237–245, 2003. View at Google Scholar · View at Scopus
  85. D. D. Karp, A. S. Tsao, and E. S. Kim, “Nonsmall-cell lung cancer: chemoprevention studies,” Seminars in Thoracic and Cardiovascular Surgery, vol. 15, no. 4, pp. 405–420, 2003. View at Publisher · View at Google Scholar · View at Scopus
  86. N. van Zandwijk and F. R. Hirsch, “Chemoprevention of lung cancer. Current status and future prospects,” Lung Cancer, vol. 42, no. 2, pp. S71–S79, 2003. View at Publisher · View at Google Scholar · View at Scopus
  87. R. M. Russell, “The enigma of β-carotene in carcinogenesis: what can be learned from animal studies,” Journal of Nutrition, vol. 134, no. 1, pp. 262S–268S, 2004. View at Google Scholar · View at Scopus
  88. A. R. Kristal, “Vitamin A, Retionoids and Carotenoids as chemo preventive agents for prostrate cancer,” Journal Of Urology, vol. 171, no. 2, pp. 54–58, 2004. View at Google Scholar
  89. M. A. Murtaugh, K.-N. Ma, J. Benson, K. Curtin, B. Caan, and M. L. Slattery, “Antioxidants, Carotenoids and risk of rectal cancer,” American Journal of Epidemiology, vol. 159, no. 1, pp. 32–41, 2004. View at Publisher · View at Google Scholar · View at Scopus
  90. S. Männistö, S. A. Smith-Warner, D. Spiegelman et al., “Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies,” Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 1, pp. 40–48, 2004. View at Publisher · View at Google Scholar · View at Scopus
  91. N. I. Krinsky, “Mechanism of action of biological antioxidants,” Proceedings of the Society for Experimental Biology and Medicine, vol. 200, no. 2, pp. 248–254, 1992. View at Google Scholar · View at Scopus
  92. A. Bendich, “Carotenoids and the immune system,” in Carotenoids: Chemisrty and Biology, N. I. Krinsky, M. M. Mathews-Roth, and R. F. Taylor, Eds., pp. 323–336, Plenum Press, NewYork, NY, USA, 1990. View at Google Scholar
  93. P. Molnár, J. Deli, T. Tanaka et al., “Carotenoids with anti-Helicobacter pylori activity from Golden delicious apple,” Phytotherapy Research, vol. 24, no. 5, pp. 644–648, 2010. View at Publisher · View at Google Scholar · View at Scopus
  94. L. Selvameenal, M. Radhakrishnan, and R. Balagurunathan, “Antibiotic pigment from desert soil actinomycetes; Biological activity, purification and chemical screening,” Indian Journal of Pharmaceutical Sciences, vol. 71, no. 5, pp. 499–504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  95. Z. S. Sathi, N. Sugimoto, M. I. Khali, and M. A. Gafur, “Isolation of yellowish antibiotic pigment 4-hydroxy Nitrobenzene from a strain of Streptomyces,” Pakistan Journal of Biological Sciences, vol. 52, pp. 201–203, 2002. View at Google Scholar
  96. C. Kim, H. Jung, J. H. Kim, and C. S. Shin, “Effect of monascus pigment derivatives on the electrophoretic mobility of bacteria, and the cell adsorption and antibacterial activities of pigments,” Colloids and Surfaces B, vol. 47, no. 2, pp. 153–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  97. S. Visalakchi and J. Muthumary, “Antimicrobial activity of the new endophytic Monodictys castaneae SVJM139 pigment and its optimization,” African Journal of Microbiology Research, vol. 4, no. 1, pp. 38–44, 2010. View at Google Scholar · View at Scopus