Table of Contents
Advances in Biology
Volume 2017, Article ID 9303276, 8 pages
Research Article

Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

1Department of Biochemistry, Imo State University, Owerri, Imo State, Nigeria
2Department of Chemical Sciences (Biochemistry Unit), Rhema University, Aba, Abia State, Nigeria
3Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, Nigeria

Correspondence should be addressed to Duru Majesty; moc.liamg@uruduwkuhcelek

Received 30 April 2016; Revised 14 September 2016; Accepted 4 October 2016; Published 19 January 2017

Academic Editor: Byung-Cheon Lee

Copyright © 2017 Agomuo Emmanuel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Effect of caffeine on some selected biochemical parameters using rat model was investigated. Standard methods of analysis were used for the study. A total of sixty (60) rats divided equally into five groups of which one group served as the control, and the rest as test groups were used. The test rats were placed on different concentrations of caffeine for twenty-eight (28) days. Results obtained for the selected biochemical parameters revealed that AST and ALT levels of the liver increased significantly () in test rats against the control. Creatinine and electrolyte ions of the kidney increased significantly () in test groups when compared to the control. Haematological indices such as WBC, monocytes, lymphocytes, MCV, MCHC, and MCV levels were significantly altered () in test rats against those of the control. It therefore becomes imperative for those that consume caffeine with believe that it does more good work than harm to take note of these findings. This study has revealed the effect of caffeine on some selected biochemical parameters using rat model.