Research Article | Open Access
Piotr Prochor, Eugeniusz Sajewicz, "A Comparative Analysis of Standardised Threads for Use in Implants for Direct Skeletal Attachment of Limb Prosthesis: A Finite Element Analysis", Applied Bionics and Biomechanics, vol. 2019, Article ID 8027064, 10 pages, 2019. https://doi.org/10.1155/2019/8027064
A Comparative Analysis of Standardised Threads for Use in Implants for Direct Skeletal Attachment of Limb Prosthesis: A Finite Element Analysis
The aim of the research was to determine the optimal thread’s shape to be used in implants for direct skeletal attachment of limb prosthesis. In addition, by testing appropriate parameters’ modification of the suitable thread, an attempt was made to maximise its effectiveness. The analyses included three thread types described in the ISO standards: shallow, symmetrical, and asymmetrical. The obtained results suggest that shallow thread ensures the lowest equivalent and directional stress peaks generated in the bone as well as favourable stress patterns and profiles during implant loading in relation to symmetrical and asymmetrical threads. Moreover, shallow thread ensured the generation of single equivalent and directional stress peaks, while symmetrical and asymmetrical threads provided additional stress peak for equivalent as well as for each of directional peaks. Subsequently, optimisation of the shallow thread’s shape was conducted by changing two relevant thread’s parameters (flank angle and rounding arc) which influence the generated stress distribution. The highest reduction of stress peaks was obtained while reducing the rounding arc by 0.2 mm. Therefore, it can be stated that the proposed modification of the HA thread can lead to obtaining a higher biomechanical effectiveness of implants for direct skeletal attachment of limb prosthesis.
Traditionally, lower limb prostheses are connected to the stump with the use of an individually fitted socket. However, due to a number of disadvantages arising from their use, such as skin abrasions and poor prosthesis control resulting from the socket loosening, physicians and engineers have started to develop new limb-prosthesis connection solutions [1–6]. One of these solutions is implants for direct skeletal attachment (DSA) of limb prosthesis. These are specially designed constructions that are implanted into the marrow cavity of the bone, with a shaft penetrating soft tissues on which the external prosthesis is attached [1–7].
One way to connect the implant for direct skeletal attachment to the bone is to use a proper thread connection. An example of the implant that uses this method is the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) [5, 8]. It is currently the most common implant solution for direct limb prosthesis in bone fixation, which includes the use of the thread. Direct skeletal attachment of limb prosthesis is currently still developing connecting method being the reason for conducting proper analyses with the use of computer or experimental methods [9–16].
Applying thread as implant anchoring element may result in occurring stress peaks thatcan cause local bone resorption. As a result, it may lead to the loosening of an implant in a bone and the necessity of its removal. This problem has been reported in studies of threaded dental implants, which may suggest possible existence of the same problem in threaded implants for bone-anchored prostheses [17–21]. Stress peaks would explain the reason of the failure in some cases of the currently proposed construction solutions of implants for DSA . The implant’s thread should reduce the stress peaks as well as provide the highest implant-bone contact area in order to ensure appropriate secondary stabilisation [18, 22, 23]. However, so far, there are no analyses that optimise a proper thread which could be used in implants for bone-anchored prostheses. Few studies present results that could be used in the process of designing an implant thread for bone-anchored prostheses [17, 24]. During the development of implants, engineers can base on numerous research optimising the shape of the dental implant’s thread [25, 26]. Nevertheless, due to the fact that the method of their attachment differs significantly from the attaching implant for direct skeletal attachment into the marrow cavity, there is no possibility of applying exactly the same thread design.
The aim of this study was to evaluate the efficiency of standardised threads, defined in appropriate standards, for use in implants for DSA of limb prosthesis. Three types of threads, commonly used in medical screws, were considered: HA: shallow thread; HC: symmetrical thread; HD: asymmetrical thread [27, 28]. Additionally, the authors attempted to modify the most appropriate standardised thread (which was determined during the analysis), in order to increase its efficiency in implant for DSA. The effectiveness of appropriate load transferring by the implants with the analysed threads was determined by comparing the stress patterns and profiles and stress peak values that were generated in the bone during different loading methods. The obtained results may allow increasing the functionality of currently used threaded implants for bone-anchored prostheses, as well as newly developed solutions.
2. Materials and Methods
2.1. Analysed Threads
In the analyses, three types of standardised threads were considered (Figure 1), which are used mostly in medical screws. However, after suitable modifications, described threads find the use as threads of dental implants [25, 27, 28].
The highest shapes of threads that have been specified in the standards were chosen for analyses (individual dimensions were approximately similar to each other). The threads were HA 5, HC 4.2, and HD 4.5. HB thread, defined in ISO 5835:1991 standard, was omitted in analyses, as it is intended for use as an anchoring element in cancellous bone. Minor diameter of each thread was set as 19.5 mm. Slight radii considered in HC and HD threads were equal 0.025 mm. Undescribed threads’ parameters are defined in the appropriate standards [27, 28].
2.2. Characteristics of Finite Element Models Created for Analyses
Analyses with the use of finite element method were performed using the Ansys Workbench 16.0 software (Ansys Inc.). Implants with appropriate threads were placed in the left femur model of an adult human (male, 44 years old, 85 kg mass, 185 cm height). In order to reflect postamputation conditions, the femur was cut in half of its length. Approximate bone shaft diameter was , while approximate marrow cavity diameter was and the length from the head to the amputation level was 237.5 mm. The implantation method reflects the positioning of the OPRA system [5, 8]. The length of the implanted part was 75.0 mm, while the initial immersion of the implant was 25.0 mm. The supports were set in the greater trochanter and femur’s head areas. The exemplary implant-bone model is shown in Figure 2.
The analyses included two loading conditions. The first was the axial loading of the implant with a force of . A given load may occur during static load bearing exercises, that is, during rehabilitation process after implantation of an implant for bone-anchored prostheses. These exercises rely on loading a head of an implant with its user’s own, most of the time, partial mass [29, 30]. The applied force occurs in case of extreme implant loading by a man of approx. 100 kg. The second loading method used in the analyses was taken from the experimental research of the OPRA system and corresponds to the highest forces that are generated on the implant’s head during the gait for a patient of 61 kg [11, 31, 32]. These are obtained during the heel strike (; ; ; ; ; ) and can lead to microcracks in bone tissues, which can result in the implant’s loosening. The loads, in both analysed cases, were applied onto the head of the implant. In order to reflect the real conditions, a suitable coefficient of friction with a value of 0.4 was applied; as in primary stabilisation, the implant is not yet osseointegrated, which can lead to its micromovement within the bone tissues . The reciprocal interaction of the implant and the bone was taken into account by applying the relevant contact elements.
To generate the implant-bone model, 10-node finite elements were used . The authors focused on analysing the implant-bone interface. For this reason, the mesh was additionally densified in abovementioned contact to obtain the exact location of stress peaks generated in the bone during implant loading. The discretisation was performed until further densifying was not changing the results more than 3% obtained as Huber-Mises-Hencky stresses. The obtained models contained approx. finite elements with maximal edge length of 3.0 mm for the implant-bone model.
Orthotropic properties of the cortical tissue were considered in the research: (radial), (transverse), (longitudinal), , , , and kg/m3 [3, 14]. Due to the fact that the implant is placed primarily in the cortical bone, for simplification, the isotropic properties of the cancellous tissue ( GPa, , and kg/m3) were used . Titanium alloy (Ti6Al4V) was set as implants’ material ( GPa, , and kg/m3) [5, 9].
3.1. Comparative Analysis of Standardised Threads
In the first part of the research, a comparative analysis of the biomechanical functionality of the included standardised HA, HC, and HD threads was conducted.
The first analysed factor was thread-bone contact area (Figure 3). According to Hansson and Werke and Lee et al., this parameter can then significantly affect the local concentrations of bone stresses arising during loading of the implant [17, 18]. Moreover, wider contact area should increase the effectiveness of implant-bone connection in secondary stability, by allowing the bone tissue to overgrow through a larger surface.
Another and at the same time the main analysed factor was stress patterns. According to Hansson and Werke, stresses concentrated in localised area are a direct cause of local bone tissue damage . The obtained results were presented as cross sections through the axis of implant-bone connection and the location of stress peak formed during implant loading (Figure 4). Stress patterns created during the heel strike differed slightly from those resulting from axial loading of the implant, while the location of stress peaks remained the same.
Stress profiles were set in order to increase the precision of conducted analyses. For this purpose, suitable paths (Figure 5) were determined, for which the equivalent and directional stresses were designated.
The authors additionally analysed the stress peak values for both loading methods. The obtained results are included in Figure 7.
3.2. Comparative Analysis of Modified HA Thread
In the second part of the research, the influence of changes in parameters of the most suitable thread defined in the first part was examined (HA thread). In both parts, the same mesh parameters, loadings, and boundary conditions were used.
The impact of changes in the two thread’s parameters was examined (Figure 8): the rounding arc (r1) and the flank angle (). The stress distribution around the thread of the implant, presented in Figures 4 and 6, suggests that these two parameters have the main influence on the load transferring efficiency. Other thread’s parameters should have then primarily impact only on implant’s anchoring effectiveness in the cortical bone. Impacts of the 4 modifications of the rounding arc (0.8 mm, 0.9 mm, 1.1 mm, and 1.2 mm) and 4 modifications of the flank angle (25°, 30°, 40°, and 45°) on generated stresses were analysed. Obtained values were compared to values obtained in the first part of the research for HA thread type with standardised parameters (rounding and flank ). Lastly, a comparative analysis of 25 thread geometries was performed.
As in the first part of the results, the thread-bone contact area was determined in the form of the influence of changes in the flank angle and the rounding arc on analysed factor (Figure 9).
The stress peak localisation did not change and remained similar as presented in Figure 6 despite the introduced constructional changes of implant-bone connection. The results of stress peak values obtained for axial loading are shown in Figure 10, while for heel strike in Figure 11.
The following article presents a comparison of the efficiency (in terms of stress distribution in bone tissues, generated while loading of the implant) of standardised threads (shallow thread HA, symmetrical thread HC, and asymmetrical HD) in implants for direct skeletal attachment of limb prosthesis [27, 28]. Currently, there are no studies that clearly determine the optimal shape of the thread for use in this type of implants. While choosing a suitable type of the thread in order to obtain proper implant-bone connection, researchers can base on studies of dental implants that use this anchoring method [17, 25, 26]. However, these implants use various types of threads from symmetrical-, trapezoidal-, to circular-shaped, which, due to their specific shape, can be used only in the mandible and maxilla. The aim of the conducted study was to determine the optimal shape of the thread for the implants for direct skeletal attachment of limb prosthesis and modify proper parameters to obtain its maximum efficiency.
One of the closest studies to the one presented by the authors is the analyses conducted by Hansson and Werke . However, the authors made an attempt to simulate implant-bone connection closer to in vivo conditions. Hansson and Werke assumed frictionless contact between the implant and the bone as well as simplified cortical bone to isotropic material. Unlike them, the authors considered the bone as an orthotropic material and used the appropriate coefficient of friction [3, 14, 32]. Due to the problem with convergence during calculation, Hansson and Werke applied inflated Young’s modulus of the cortical bone. The authors used appropriate and actual Young’s modulus value [35, 36]. Because of the adopted simplifications, Hansson and Werke focused on principal stress, while the authors of the paper decided to examine equivalent Huber-Mises-Hencky as well as directional stress peaks. Analysing the location of individual stress peaks may contribute to a better understanding of the mechanics of connection between threaded implants for direct skeletal attachment of limb prosthesis and bone tissues. Additionally, Hansson and Werke in their analyses considered a single implant member, while the authors of the presented paper analysed a complete model of the implant placed in the femur. This method greatly increased the computing time; however, it led to obtaining more appropriate load transfer from implant into bone tissues. The use of the described parameters allowed the authors for a better reflection of the actual implant-bone connection. As Hansson’s simplification, the authors took into consideration the full contact of the implant with the bone.
4.1. A Comparison of the Effectiveness of HA, HC, and HD Threads
All stress peaks, equivalent and directional, were created in the area of the thread crest, which suggests that it is a region of possible bone resorption which occurs due to bone overloading. Obtained results are confirmed in other finite element and experimental thread analyses [17, 25, 26]. The described feature was observed in all types of analysed threads and can be the reason for the loosening of implants in the bone tissues. It leads to the necessity of its removal, which was reported in clinical experiments [17–21]. Moreover, the results obtained for axial and heel strike loadings present similarities both in the case of stress peak values as well as stress patterns and profiles. Therefore, it can be assumed that axial force is the main factor in the generation of stress peaks.
On the basis of the obtained results, it can be concluded that the optimal thread type (from the analysed types) for use in implants for DSA of limb prosthesis is the HA thread. It is determined due to the lowest equivalent and directional stress peak values that are generated in the bone during implant loading from all analysed thread-bone connections. Furthermore, high-value stresses generated as a result of stress peak decrease in the HA thread type much faster than in other types. Additionally, the use of HA threads significantly reduces radial (4.0 MPa and 6.5 MPa for HA and HD, respectively, during axial loading and 3.1 MPa and 5.1 MPa during heel strike) stress peaks. This is especially important due to the susceptibility of the bone on shear stress, which is one of the main reasons for bone resorption around the threaded implant. What is more, in the analysis of stress profiles generated in the case of HC and HD threads, there can be noted a second stress peak (equivalent and directional) with about 30% lower value. This indicates the existence of a second potential bone resorption site due to a sudden stress increase.
The results suggest that the least favourable is the HC thread around which the equivalent stress peak was created with the highest value reaching approx. 16.6 MPa during axial loading and 12.9 MPa during heel strike—HA generated 13.4 MPa and 10.3 MPa, while HD generated 14.7 MPa and 11.4 MPa, respectively, for axial and heel strike loadings. However, the HC thread provided lower radial stress peak (6.2 MPa for axial loading, 4.7 MPa for heel strike) than the HD thread (6.5 MPa for axial loading, 5.1 MPa for heel strike).
In the analyses, the impact of thread-bone contact area on stress peaks was not observed. Nevertheless, it should be remembered that higher contact area between an implant and a bone allows for obtaining a more stable secondary connection. For this reason, the implant construction should consider a thread that provides both, small values of stress peaks and a correspondingly large implant-bone contact area.
4.2. A Comparison of the Effectiveness of Modified HA Threads
The modification of the rounding arc by 0.2 mm and the flank angle by 15° from the standardised values (1.0 mm for the rounding arc and 30° for the flank angle) allows changing the thread-bone contact area by approx. 6.5%. This variation modifies the implant-bone interface affecting the probability of achieving adequate osseointegration during secondary stabilisation.
In the case of axial loading, the highest values of analysed stress peaks were generated at a flank angle of 25°. Moreover, the longitudinal stress peak was equally unfavourable at a 45° flank angle. Similar dependencies were observed in the case of heel strike, but in this case, equivalent and longitudinal stress peaks were the highest with a flank angle of 45°. Additionally, as in the axial loading, the radial and transverse stress peaks were characterised by the highest value at a flank angle of 25°. The lowest values of equivalent and longitudinal stress peaks during axial loading, as well as heel strike, were produced at a standard flank angle of 35°, while the lowest values of radial and transverse stress peaks were produced at 45°. Decreasing rounding arc caused an increase in the value of all stress peaks in each of the analysed cases.
The most favourable stress peak reduction was obtained by modifying only the rounding arc increasing it by 0.2 mm, leaving the flank angle at a normalised value of 35°. The described modification in the case of axial loading allows to reduce the equivalent stress peak by 1.7%, radial stress peak by 6.9%, transverse stress peak by 3.5%, and longitudinal stress peak by 1.7%. In the case of heel strike, this modification reduces the equivalent stress peak by 1.0%, radial stress peak by 4.9%, transverse stress peak by 2.1%, and longitudinal stress peak by 0.9%.
4.3. Limitations of the Study
The assumptions considered by the authors are characterised by certain simplifications in relation to real conditions. Among them there can be specified full contact of the implant with the bone, orthotropic and isotropic properties of the cortical and cancellous bones, respectively, or omitting the influence of body fluids as well as bacteria that often settle in the implant-bone interface. The impact of the stump muscles was also ignored.
The most appropriate standardised thread for use in implants for direct skeletal attachment of limb prosthesis is the HA thread type. It provides the lowest stress peaks’ values and the most favourable stress pattern and profile.
The modification of the standardised HA thread by reducing the rounding arc by 0.2 mm allows for the reduction of the stress peak values in relation to the stress peaks generated in the bone around the standard HA thread. However, it should be remembered that this reduction also reduces the thread-bone contact area by 3.7%, which may decrease the probability of achieving proper osseointegration in secondary stabilisation.
The presented dependencies allow for the selection of a suitable thread for implants for the direct skeletal attachment of limb prosthesis and may lead to further research on the thread directly dedicated to implants for bone-anchored prostheses.
No data were used to support this study.
Conflicts of Interest
The authors declare that there is no conflict of interest regarding the publication of this paper.
This work was supported by the National Science Centre, Poland (grant number 2016/23/N/ST8/03526).
- T. Albrektsson and B. Albrektsson, “Osseointegration of bone implants, a review of an alternative mode of fixation,” Acta Orthopaedica Scandinavica, vol. 58, no. 5, pp. 567–577, 1987.
- R. Brånemark, O. Berlin, K. Hagberg, P. Bergh, B. Gunterberg, and B. Rydevik, “A novel osseointegrated percutaneous prosthetic system for the treatment of patients with transfemoral amputation: a prospective study of 51 patients,” The bone & Joint Journal, vol. 96-B, no. 1, pp. 106–113, 2014.
- D. M. Collins, A. Karmarkar, R. Relich, P. F. Pasquina, and R. A. Cooper, “Review of research on prosthetic devices for lower extremity amputation,” Critical Reviews in Biomedical Engineering, vol. 34, no. 5, pp. 379–438, 2006.
- A. Nebergall, C. Bragdon, A. Antonellis, J. Kärrholm, R. Brånemark, and H. Malchau, “Stable fixation of an osseointegated implant system for above-the-knee amputees: titel RSA and radiographic evaluation of migration and bone remodeling in 55 cases,” Acta Orthopaedica, vol. 83, no. 2, pp. 121–128, 2012.
- M. Pitkin, “Design features of implants for direct skeletal attachment of limb prostheses,” Journal of Biomedical Materials Research Part A, vol. 101, no. 11, pp. 3339–3348, 2013.
- J. Tillander, K. Hagberg, L. Hagberg, and R. Brånemark, “Osseointegrated titanium implants for limb prostheses attachments: infectious complications,” Clinical Orthopaedics and Related Research®, vol. 468, no. 10, pp. 2781–2788, 2010.
- M. Lennerås, G. Tsikandylakis, M. Trobos et al., “The clinical, radiological, microbiological, and molecular profile of the skin-penetration site of transfemoral amputees treated with bone-anchored prostheses,” Journal of Biomedical Materials Research. Part A, vol. 105, no. 2, pp. 578–589, 2017.
- W. Vanhove, S. Vertriest, S. Geers, J. Victor, G. Vanderstraeten, and S. Rimbaut, “Skeletal fixation of the exoprosthesis by an osseointegrated implant (OPRA) in amputees,” Annals of Physical and Rehabilitation Medicine, vol. 56, pp. e24–e25, 2013.
- L. Frossard, D. L. Gow, K. Hagberg et al., “Apparatus for monitoring load bearing rehabilitation exercises of a transfemoral amputee fitted with an osseointegrated fixation: a proof-of-concept study,” Gait & Posture, vol. 31, no. 2, pp. 223–228, 2010.
- B. Helgason, H. Pálsson, T. P. Rúnarsson, L. Frossard, and M. Viceconti, “Risk of failure during gait for direct skeletal attachment of a femoral prosthesis: a finite element study,” Medical Engineering & Physics, vol. 31, no. 5, pp. 595–600, 2009.
- W. C. C. Lee, L. A. Frossard, K. Hagberg et al., “Kinetics of transfemoral amputees with osseointegrated fixation performing common activities of daily living,” Clinical biomechanics, vol. 22, no. 6, pp. 665–673, 2007.
- A. Pantall, S. Durham, and D. Ewins, “Surface electromyographic activity of five residual limb muscles recorded during isometric contraction in transfemoral amputees with osseointegrated prostheses,” Clinical biomechanics, vol. 26, no. 7, pp. 760–765, 2011.
- P. Prochor, S. Piszczatowski, and E. Sajewicz, “Biomechanical evaluation of a novel limb prosthesis osseointegrated fixation system designed to combine the advantages of interference-fit and threaded solutions,” Acta of Bioengineering and Biomechanics, vol. 18, no. 4, pp. 21–31, 2016.
- M. Schwarze, C. Hurschler, F. Seehaus, T. Correa, and B. Welke, “Influence of transfemoral amputation length on resulting loads at the osseointegrated prosthesis fixation during walking and falling,” Clinical biomechanics, vol. 29, no. 3, pp. 272–276, 2014.
- T. J. Shelton, J. Peter Beck, R. D. Bloebaum, and K. N. Bachus, “Percutaneous osseointegrated prostheses for amputees: limb compensation in a 12-month ovine model,” Journal of Biomechanics, vol. 44, no. 15, pp. 2601–2606, 2011.
- R. Tranberg, R. Zügner, and J. Kärrholm, “Improvements in hip- and pelvic motion for patients with osseointegrated trans-femoral prostheses,” Gait & Posture, vol. 33, no. 2, pp. 165–168, 2011.
- S. Hansson and M. Werke, “The implant thread as a retention element in cortical bone: the effect of thread size and thread profile: a finite element study,” Journal of Biomechanics, vol. 36, no. 9, pp. 1247–1258, 2003.
- C. C. Lee, S. C. Lin, M. J. Kang, S. W. Wu, and P. Y. Fu, “Effects of implant threads on the contact area and stress distribution of marginal bone,” Journal of Dental Sciences, vol. 5, no. 3, pp. 156–165, 2010.
- L. Baggi, I. Cappelloni, M. Di Girolamo, F. Maceri, and G. Vairo, “The influence of implant diameter and length on stress distribution of osseointegrated implants related to crestal bone geometry: a three-dimensional finite element analysis,” The Journal of Prosthetic Dentistry, vol. 100, no. 6, pp. 422–431, 2008.
- H. S. Ryu, C. Namgung, J. H. Lee, and Y. J. Lim, “The influence of thread geometry on implant osseointegration under immediate loading: a literature review,” The Journal of Advanced Prosthodontics, vol. 6, no. 6, pp. 547–554, 2014.
- S. Hansson, “A conical implant-abutment interface at the level of the marginal bone improves the distribution of stresses in the supporting bone. An axisymmetric finite element analysis,” Clinical Oral Implants Research, vol. 14, no. 3, pp. 286–293, 2003.
- M. Akkocaoglu, S. Uysal, I. Tekdemir, K. Akca, and M. C. Cehreli, “Implant design and intraosseous stability of immediately placed implants: a human cadaver study,” Clinical Oral Implants Research, vol. 16, no. 2, pp. 202–209, 2005.
- L. Vidyasagar and P. Apse, “Dental implant design and biological effects on bone-implant interface,” Stomatologija, vol. 6, pp. 51–54, 2004.
- W. C. C. Lee, J. M. Doocey, R. Brånemark et al., “FE stress analysis of the interface between the bone and an osseointegrated implant for amputees--implications to refine the rehabilitation program,” Clinical biomechanics, vol. 23, no. 10, pp. 1243–1250, 2008.
- J. P. Geng, W. Xu, K. B. C. Tan, and G. R. Liu, “Finite element analysis of an osseointegrated stepped screw dental implant,” The Journal of Oral Implantology, vol. 30, no. 4, pp. 223–233, 2004.
- P. Marcián, L. Borák, J. Valášek, J. Kaiser, Z. Florian, and J. Wolff, “Finite element analysis of dental implant loading on atrophic and non-atrophic cancellous and cortical mandibular bone - a feasibility study,” Journal of Biomechanics, vol. 47, no. 16, pp. 3830–3836, 2014.
- Standard ISO 5835, “Implants for surgery - metal bone screws with hexagonal drive connection, spherical under-surface of head, asymmetrical thread,” Dimensions, 1991.
- Standard ISO 9268, “Implants for surgery - metal bone screws with conical under-surface of head,” Dimensions, 1988.
- S. Vertriest, P. Coorevits, K. Hagberg et al., “Static load bearing exercises of individuals with transfemoral amputation fitted with an osseointegrated implant: reliability of kinetic data,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 23, no. 3, pp. 423–430, 2015.
- S. Vertriest, P. Coorevits, K. Hagberg et al., “Static load bearing exercises of individuals with transfemoral amputation fitted with an osseointegrated implant: loading compliance,” Prosthetics and Orthotics International, vol. 41, no. 4, pp. 393–401, 2016.
- L. A. Frossard, R. Tranberg, E. Haggstrom, M. Pearcy, and R. Brånemark, “Load on osseointegrated fixation of a transfemoral amputee during a fall: loading, descent, impact and recovery analysis,” Prosthetics and Orthotics International, vol. 34, no. 1, pp. 85–97, 2010.
- P. K. Tomaszewski, N. Verdonschot, S. K. Bulstra, and G. J. Verkerke, “A comparative finite element analysis of bone failure and load transfer of osseointegrated prostheses fixations,” Annals of Biomedical Engineering, vol. 38, no. 7, pp. 2418–2427, 2010.
- Ansys, Inc, “Ansys mechanical APDL element reference,” Release, vol. 15, 2013.
- L. Capitanu, V. Florescu, and L. L. Badita, “New concept in durability improvement of hip total joint endoprostheses,” Acta of Bioengineering and Biomechanics, vol. 16, no. 1, pp. 75–82, 2014.
- R. B. Ashman, S. C. Cowin, W. C. Van Buskirk, and J. C. Rice, “A continuous wave technique for the measurement of the elastic properties of cortical bone,” Journal of Biomechanics, vol. 17, no. 5, pp. 349–361, 1984.
- Y. Li, C. Yang, H. Zhao, S. Qu, X. Li, and Y. Li, “New developments of Ti-based alloys for biomedical applications,” Materials, vol. 7, no. 3, pp. 1709–1800, 2014.
Copyright © 2019 Piotr Prochor and Eugeniusz Sajewicz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.