Finding Biomarker Signatures in Pooled Sample Designs: A Simulation Framework for Methodological Comparisons

Figure 1

Single sample design and pooling design for class comparison. Design 𝐼 (single samples) and design 𝐼𝐼 (pooled samples) for the comparison of class 𝐴 and class 𝐵. In design 𝐼 one sample is analysed on a single array. In design 𝐼𝐼, at first, pools are built with identical size. Afterwards each pool is hybridized on an array.