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Advances in Bioinformatics
Volume 2010, Article ID 856825, 7 pages
Research Article

Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection

1Laboratory of Computational Oncology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
2Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Rd, Pokfulam, Hong Kong

Received 25 August 2009; Revised 31 December 2009; Accepted 10 February 2010

Academic Editor: Igor B. Rogozin

Copyright © 2010 Clara S. M. Tang and Richard J. Epstein. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Inverse relationship between GC content and Ka/Ks. Genes encoding olfactory receptors (golden triangles), which are known to undergo positive selection, and structurally related taste receptors–including vomeronasal receptors, which are non-functional in humans–were used to exemplify the relationship within a data set which is expected to be enriched for pseudogenization.

  1. Supplementary Material