Research Article

Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection

Table 1

Mean expression score (breadth and SAGE) of varying Ka/Ks groups for low and high GC genes. The data confirm that the different Ka/Ks groups so defined vary significantly in terms of gene expression levels for both low-GC (correlation coefficient , ) and high-GC gene subsets (correlation coefficient , ), as well as in terms of expression breadth (correlation coefficient , , and correlation coefficient , , resp.) using Spearman correlation.

Ka/KsBreadthSAGE
Low GCHigh GCLow GCHigh GC

0
0–0.1
0.1–0.2
0.2