Review Article

Inferring Biological Mechanisms by Data-Based Mathematical Modelling: Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case

Figure 5

Economic efficiency. (a) Binding of AA to ADP-bound AB reduces the amount of active kinase and thus slows down the cycles of phosphorylation and dephosphorylation of AA. (b) The amount of ATP per 𝜎 𝐹 released per minute drops sharply as the fraction of AB that is sequestered in inactive AB-ADP-AA complexes sharply increases at the time of septation (time 𝑡 = 0 ).
124062.fig.005a
(a)
124062.fig.005b
(b)