Inferring Biological Mechanisms by Data-Based Mathematical Modelling: Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case
Figure 6
Operons and molecular noise. (a) The spoIIA operon comprises the genes for SpoIIAA, SpoIIAB, and . The genes for SpoIIAA and SpoIIAB overlap; the genes for SpoIIAB and are separated by 11 bp. The impact of stochastic variation in gene expression on sporulation efficiency. (b) The fraction of successful sporulation events depend on the variance in gene expression if expression of the spoIIA genes is either coupled (black lines), the expression of SpoIIAB and is coupled (grey lines), or the expression of SpoIIAA and is coupled (blue lines). The broken lines show the effect of an additional independent normal variation in the rate of expression from the coupled rates. (a) and (b) have been reproduced from [48].
