Cotranslational Protein Folding and Terminus Hydrophobicity

Figure 1

Three results, independently showing that a reduction in hydrophobicity from start to end is associated with cotranslational folding, are summarised. These are (1) a positive correlation between the difference (N−C) in terminus hydrophobicity and cotranslational folding in HP models, (2) a positive correlation between ALR (considered a measure of cotranslational folding in real proteins) and the difference in terminus hydrophobicity, and (3) real proteins that fold more successfully using a cotranslationally based structure prediction algorithm have more hydrophobic N-terminus than C-terminus.