Research Article
Maximum Recommended Dosage of Lithium for Pregnant Women Based on a PBPK Model for Lithium Absorption
| | Conversion factor for lithium content of drug dose | 8/300 | mEq (mmol) Li/mg dose | [3] |
| | Bone mass | 8 | kg | [14] |
| | Bone density | 1.1 | g/mL | [15] |
| | Kidney clearance rate () | 20 | mL/min | [3] |
| | Physiological volumes of organ/tissue compartments |
| | Plasma () | 5200 | mL | [16] | | Bone () | 7273 | mL | Calculated from bone mass and bone density | | Kidney () | 280 | mL | [16] | | Uterus () | 1000 | mL | [7] | | Gastrointestinal (GI) tract () | 1650 | mL | [16] | | Thyroid () | 13 | mL | [16] | | Brain () | 1450 | mL | [16] | | Fetus, 1st Trimester () | 150 | mL | [7] |
| | Blood flow to organs |
| | Bone () | 272 | mL/min | Calculated from bone perfusion and bone mass [14] | | Kidney () | 1240 | mL/min | [16] | | Uterus () | 475 | mL/min | [7] | | GI Tract () | 1100 | mL/min | [16] | | Thyroid () | 60 | mL/min | Modeled based on similar sized organs | | Brain () | 700 | mL/min | [16] | | Fetus, 1st trimester () | 300 | mL/min | [7] |
| | Tissue to plasma equilibrium distribution ratios for lithium |
| | Bone () | 1.5 | | [3] | | Kidney () | 1 | | [3] | | Uterus () | 0.4 | | [3] | | GI Tract () | 1 | | [3] | | Thyroid () | 1.5 | | [3] | | Brain () | 1.5 | | [3] | | Fetus () | 0.8 | | Estimated; see rationale in text |
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