Table 1: Model parameters.

Conversion factor for lithium content of drug dose8/300mEq (mmol) Li/mg dose[3]

Bone mass8kg[14]

Bone density1.1g/mL[15]

Kidney clearance rate ( )20mL/min[3]

Physiological volumes of organ/tissue compartments

Plasma ( )5200mL[16]
Bone ( )7273mLCalculated from bone mass and bone density
Kidney ( )280mL[16]
Uterus ( )1000mL[7]
Gastrointestinal (GI) tract ( )1650mL[16]
Thyroid ( )13mL[16]
Brain ( )1450mL[16]
Fetus, 1st Trimester ( )150mL[7]

Blood flow to organs

Bone ( )272mL/minCalculated from bone perfusion and bone mass [14]
Kidney ( )1240mL/min[16]
Uterus ( )475mL/min[7]
GI Tract ( )1100mL/min[16]
Thyroid ( )60mL/minModeled based on similar sized organs
Brain ( )700mL/min[16]
Fetus, 1st trimester ( )300mL/min[7]

Tissue to plasma equilibrium distribution ratios for lithium

Bone ( )1.5[3]
Kidney ( )1[3]
Uterus ( )0.4[3]
GI Tract ( )1[3]
Thyroid ( )1.5[3]
Brain ( )1.5[3]
Fetus ( )0.8Estimated; see rationale in text