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Advances in Bioinformatics
Volume 2012 (2012), Article ID 453513, 9 pages
Research Article

Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players

1Metabolic Engineering and Bioinformatics Program, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas. Constantinou Avenue, 11635 Athens, Greece
2Division of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro SE-701 82, Sweden
3Biotechnology Laboratory, School of Chemical Engineering, Zografou Campus, National Technical University of Athens, 15780 Athens, Greece

Received 25 May 2012; Accepted 21 September 2012

Academic Editor: Konstantina Nikita

Copyright © 2012 Olga Papadodima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1: List of significantly differentiated probesets. ANOVA analysis between fold changes in expression of ApoE knockout and wild type mice, in three different ages, yielded a list of 1033 significantly differentiated probesets.

Supplementary Table 2: Kegg pathways based analysis. The list of 852 significantly altered genes was submitted to StRAnGER analysis, elucidating over-represented Kegg terms. Kegg term P value represents the hypergeometric test P value score for each Kegg term. Enrichment represents the ratio of the number of times a Kegg term occurs in the 852 gene list to the number of times this term exists in the list of the Affymetrix 430 2.0 array.

  1. Supplementary Table 1
  2. Supplementary Table 2