Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players

Table 2

Expression of genes under the GO term immune response. Values in the three last columns depict fold changes between ApoE knockout and age-matched wild type mice in log2 scale. The majority of genes at 32 and 78 weeks are upregulated.

Symbol	Description	6 weeks	32 weeks	78 weeks
Ccl6	Chemokine (C-C motif) ligand 6	−0.17	2.25	2.23
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.29	1.56	1.43
C1qb	Complement component 1, q subcomponent, beta polypeptide	−0.23	2.28	2.43
H2-Ab1	Histocompatibility 2, class II antigen A, beta 1	−0.25	1.94	2.77
C1qa	Complement component 1, q subcomponent, a polypeptide	−0.08	1.98	2.18
Tlr2	Toll-like receptor 2	0.14	0.99	1.38
Ccl7	Chemokine (C-C motif) ligand 7	−0.98	1.59	4.42
C4b	Complement component 4B (Childo blood group)	0.23	1.2	1.74
Cblb	Casitas B-lineage lymphoma b	0.2	0.34	1.36
Fcgr2b	Fc receptor, IgG, low affinity IIb	−0.1	1.93	2.19
Cd300lb	CD300 antigen like family member B	−0.46	2.83	2.87
Susd2	Sushi domain containing 2	0.22	−0.08	−1.07
Ccl8	Chemokine (C-C motif) ligand 8	0.33	2.92	3.01
Cd14	CD14 antigen	−0.14	1.52	2.44
Fcgr1	Fc receptor, IgG, high affinity I	−0.05	1.82	2.03
Cadm1	Cell adhesion molecule 1	−0.57	1.5	2.01
C2	Complement component 2 (within H-2S)	−0.81	1.02	−0.03
Clec7a	C-type lectin domain family 7, member a	0.15	3.52	3.86
Procr	Protein C receptor, endothelial	−0.25	0.77	1.02
C1qc	Complement component 1, q subcomponent, C chain	−0.22	2.22	2.25
Ccl19	Chemokine (C-C motif) ligand 19	−0.71	1.07	1.64
Enpp3	Ectonucleotide pyrophosphatase/phosphodiesterase 3	0.24	−0.00	−1.28
Cx3cl1	Chemokine (C-X3-C motif) ligand 1	0.18	1.71	1.87
Ccl9	Chemokine (C-C motif) ligand 9	−0.46	1.74	2.19
H2-Eb1	Histocompatibility 2, class II antigen E beta	0.19	1.62	2.17
H2-Aa	Histocompatibility 2, class II antigen A, alpha	0.95	2.39	2.34
Cxcl12	Chemokine (C-X-C motif) ligand 12	−0.34	1.1	1.95
Enpp1	Ectonucleotide pyrophosphatase/phosphodiesterase 1	0.14	0.37	1.08
Rnf19b	Ring finger protein 19B	−0.29	0.73	2.58
Prg4	Proteoglycan 4	0.16	3.33	3.99
Irf8	Interferon regulatory factor 8	0.28	1.9	2.61
Cxcl1	Chemokine (C-X-C motif) ligand 1	−0.46	1.77	2.66