Application of an Integrative Computational Framework in Trancriptomic Data of Atherosclerotic Mice Suggests Numerous Molecular Players

Table 4

GOrevenge prioritization. The second column refers to the number of GO terms remaining after Gorevenge pruning, reflecting the centrality of each gene, while the third column refers to the original number of biological process category GO terms of each gene. Values in the three last columns depict fold changes between ApoE knockout and age-matched wild type mice in log2 scale. All presented genes are also differentially expressed. Top 20 genes are shown.

Gene symbol	Remaining GO terms	Original GO terms	6 weeks	32 weeks	78 weeks
Wnt5a	63	112	0.04	−0.38	−1.9
Fgfr2	56	92	0.15	−0.39	−1.05
P2rx7	38	73	0.02	0.61	1.84
Igf1	34	56	−0.23	0.77	1.39
Thbs1	30	42	−0.02	1.59	1.99
Ptgs2	30	37	−0.27	1.76	1.7
Foxf1a	28	34	0.09	−0.63	−1.41
Psen2	25	37	−0.4	0.23	1.02
Ccnd1	24	37	−0.01	0.67	1.07
Slc11a1	24	40	−0.16	1.29	1.9
Lyn	24	33	−0.01	1.07	2.26
Cebpa	24	30	−0.3	0.21	1.77
Tlr2	21	47	0.14	0.99	1.38
Osr1	21	33	0.09	0.08	−1.41
Hexb	19	23	−0.04	0.67	1
Col1a1	19	29	0.02	0.57	1.01
Socs3	19	27	0.58	1.59	3.19
Adam17	18	29	−0.22	0.27	1.07
Cd44	18	20	0.15	1.46	1.63
Cln8	18	26	0.37	0.85	1.71