Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens

Table 3

The Δ data result of the best ligands binding toward HDAC class II Homo sapiens.

Ligand	Gibbs free energy (Δ) towards HDAC class II Homo sapiens
	HDAC4	HDAC5	HDAC6	HDAC7	HDAC9	HDAC10
Nova2 (9058064-6)	−25,83	−28,94	−29,43	−31,33	−25,24	−24,01
Nova2 (95752-88-8)	−18,25	−31,67	−28,87	−28,14	−26,74	−25,96
Nova2 (88765-82-6)	−23,63	−29,22	−28,20	−25,41	−24,20	−23,32
Nova2 (Unique10)	−23,79	−29,14	−27,58	−26,66	−24,39	−20,90
Nova2 (16876-27-0)	−16,96	−27,72	−25,88	−24,31	−24,80	−22,84
Nova2 (513246-99-6)	−22,69	−28,57	−27,01	−26,72	−24,92	−21,75
Nova2 (Unique80)	−22,14	−25,00	−26,80	−24,51	−23,43	−20,83
Nova2 (279262-23-6)	−22,13	−27,46	−26,04	−27,09	−24,25	−20,68
SAHA	−13,93	−17,28	−15,35	−14,54	−16,19	−15,37
TSA	−14,65	−15,21	−14,69	−13,50	−14,28	−13,01

Note: numbers in bold show the lowest binding energy.