Utilization of Boron Compounds for the Modification of Suberoyl Anilide Hydroxamic Acid as Inhibitor of Histone Deacetylase Class II Homo sapiens

Table 4

The inhibition constant (p) of ligand binding with HDAC class II Homo sapiens.

Ligand	Inhibition constant (p)
	HDAC4	HDAC5	HDAC6	HDAC7	HDAC9	HDAC10
Nova2 (9058064-6)	18,82	21,09	21,44	22,82	18,39	17,49
Nova2 (95752-88-8)	13,30	23,07	21,03	20,50	19,48	18,92
Nova2 (88765-82-6)	17,21	21,29	20,54	18,51	17,63	16,99
Nova2 (Unique10)	17,33	21,23	20,09	19,42	17,77	15,23
Nova2 (16876-27-0)	12,36	20,20	18,86	17,71	18,07	16,64
Nova2 (513246-99-6)	16,53	20,81	19,68	19,47	18,15	15,85
Nova2 (Unique80)	16,13	18,21	19,53	17,86	17,07	15,18
Nova2 (279262-23-6)	16,13	20,01	18,97	19,73	17,67	15,07
SAHA	10,15	12,59	11,19	10,59	11,80	11,20
TSA	10,68	11,08	10,70	9,84	10,40	9,48