Alternate Phosphorylation/O-GlcNAc Modification on Human Insulin IRSs: A Road towards Impaired Insulin Signaling in Alzheimer and Diabetes

Figure 8

Space filled model of human IRS-1 protein showing higher surface accessibility of possible therapeutic yin yang residues for interplay between phosphorylation and O-glycosylation. Blue and green colours denote the Ser and Thr residues, respectively.