Ligand Based Pharmacophore Modeling and Virtual Screening Studies to Design Novel HDAC2 Inhibitors

<div>The best pharmacophore model (Hypo1) of HDAC2 inhibitors generated by the HypoGen module: (a) the best pharmacophore model Hypo1 represented with distance constraints (Å), (b) Hypo1 mapping with one of the active compounds 15, and (c) Hypo1 mapping with one of the least active compounds 29. Pharmacophoric features are colored as follows: hydrogen bond acceptor (green), hydrogen bond donor (magenta), hydrophobic (cyan), and ring aromatic (orange).</div>

Advances in Bioinformatics

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Figure 1

Figure 1: Ligand Based Pharmacophore Modeling and Virtual Screening Studies to Design Novel HDAC2 Inhibitors 