Local Mutational Pressures in Genomes of Zaire Ebolavirus and Marburg Virus

Table 4

Directions of mutational pressure in coding regions and their fragments for Zaire ebolavirus according to the “VVTAK VarInvar” algorithm results. Nucleotide usages in fourfold degenerated invariable and stable sites are compared.

Gene/fragment	NP; part 1	NP; part 2	VP35	VP40	GP; part 1	GP; part 2	GP; part 3	VP30	VP24	LP
Cytosine usage
Direction
Invariable	16,04%	28,18%	15,52%	27,05%	19,17%	30,16%	18,75%	17,53%	18,07%	14,22%
Stable	17,66%	27,18%	17,40%	25,10%	20,01%	28,77%	18,95%	20,37%	20,42%	16,11%
Guanine usage
Direction
Invariable	16,98%	12,73%	9,48%	14,75%	19,17%	14,29%	18,75%	15,46%	22,89%	12,97%
Stable	16,58%	15,13%	11,60%	15,41%	18,33%	15,88%	19,41%	14,01%	22,89%	15,48%
Uracil usage
Direction
Invariable	33,96%	23,64%	35,34%	21,31%	27,50%	22,22%	25,00%	25,77%	28,92%	33,75%
Stable	34,51%	26,24%	34,38%	26,50%	28,06%	23,54%	28,33%	25,33%	26,96%	31,46%
Adenine usage
Direction
Invariable	33,02%	35,45%	39,66%	36,89%	34,17%	33,33%	37,50%	41,24%	30,12%	39,06%
Stable	31,24%	31,45%	36,63%	32,99%	33,60%	31,82%	33,31%	40,29%	29,73%	36,95%