Expressing Redundancy among Linear-Epitope Sequence Data Based on Residue-Level Physicochemical Similarity in the Context of Antigenic Cross-Reaction

Figure 3

IEDB T-Cell Search facility interface (http://www.iedb.org/advancedQueryTcell.php). Example shown corresponds to narrow search for class I MHC-restricted T-cell assays with positive data on cross-reactivity between epitopes differing by only a single amino-acid residue substitution. Searches for B-cell assays were performed using IEDB B-Cell Search facility interface (http://www.iedb.org/advancedQueryBcell.php) of analogous form (e.g., without assay-related fields for “MHC allele”); narrow searches for negative data were performed without specified value for field labeled as “Epitope Structure Defines”; and broad searches were performed without specified value for both said field and that named “Qualitative Measurement” (see main text for additional details.).