Expressing Redundancy among Linear-Epitope Sequence Data Based on Residue-Level Physicochemical Similarity in the Context of Antigenic Cross-Reaction

Figure 6

Peptidic epitope sequence data from IEDB for B-cell assays (a) and for T-cell assays of MHC restriction class I (b) or II (c). Sequence counts (“□”) are total epitope counts in IEDB. Corresponding reduced counts ( in (1)) are expressed as the difference (sequence count − reduced count), with functional similarity equated with either fractional aligned-sequence identity (“”; (3) and (4)) or the Shannon information entropy for differential epitope binding (“△”; (5) through (9)). Missing “□” indicates sequence count = 0 (e.g., for B-cell epitope sequence length < 4 in (a)), where “□” is present and missing “” or “△” indicates sequence count − reduced count = 0 (e.g., with missing “△” for B-cell epitope sequence length = 5 in (a)). Both “” and “△” are missing where sequence count = 1 (e.g., for B-cell epitope sequence length = 43 in (a)), as reduced count = 1 for sequence count = 1.

(a)

(b)

(c)