Table 2: List of H-bonding interactions observed in Ago2-siRNA complexes. The superscripts “B” and “P” represent the interaction of Ago2 with base and phosphate groups of siRNA, respectively.

128R251R341R383R537R1113R1115R

UP523, T526, Q548, N551UT526CQ548AUK355, Q548CQ548U
GGAR792CK550
K566, R792
CT559, K566
Y529
UR792UN551, Y529, Q545
AY790, R792GY790, R792AR792CY790AY790, R792CY790, R792AY790, R792
GS798AS798, Y804CAS798US798, Y804UR795
V797, S798, Y804
GS798, Y804
AK709, R761UK709, R761CUQ757 K709CK709UAK709
CR761GR375, R761GR761AR761UR761AR761GR761
AR761AR761AR761AUUR761CR351
CGR710AR710GGR710AR710C
UR635, R710AR635CAR710GC352 R635GA
GCR351AH634
R635
AR710CR710UH634
R635
C
GR179AGR351CR635, S672UR179GR710
S672
U
AGR97GR97UUR351GR97A
UAR351AK65UQ675UCU
UUK266CCGK266UK266A
CK65GK266, K278CUCK65 K278CA
CK266, R280CD64, K65UD125CUK124UD125G
UUR280GD122 R277CR277UGA
GD125UAAAAG
UR277CAR315AGCUR277
UQ297UK335UUAUU