Table 3: ClusPro ranking of docked complex based on cluster size (member), where peptides with () represent the experimentally validated against MERS-CoV and are considered as positive controls.

Rank Peptide Length DefinitionSpecies Representative Member

1 AP0016625Pleurocidin Fish Center 134
2 AP0064133Pardaxin 1 Fish Center 134
3 AP0014423Magainin 2 Frog Center 117
4 AP0077123Magainin 1 Frog Center 117
5 AP0164430Brevinin-2-RN1 Frog Center 117
6 AP0076424Dermaseptin-S9 Frog Center 110
7 AP0257131Cycloviolacin VY1 (cyclotides) Plant Center 110
8 AP0027531Circulin B (cyclotides) Plant Center 107
9 AP0102231Cycloviolin A (cyclotides) Plant Center 107
10 AP0106131Circulin D (cyclotides) Plant Center 107
11 AP0054940Plectasin (fungal defensin) Fungus Center 101
12 AP0072929Kalata B1 (cyclotides) Plant Center 101
13 AP0073031Kalata B8 (cyclotides) Plant Center 101
14 AP0106531Cycloviolacin 014 (cyclotides) Plant Center 101
15 AP0178843Myticin C molluscs Center 97
16 AP0135646Cp-thionin II Plant Center 93
17 AP0074242Chicken AvBD6 (Beta def) Chicken Center 87
18 AP0214850Apl-AvBD16 (Beta def) Bird Center 87
19 AP0084643Mundticin KS (Bacteriocin) Bacteria Center 83
20 AP0053220Lunatusin Plant Center 78
21 P930Mouse Beta-defensin Mouse Center 68
22 AP0069230HFIAP-3 (Hagfish cathelicidin) Fish Center 67
23 AP0003638Bovine Beta-defensin 1 Bovine Center 66
24 AP0007424Brevinin-1 Frog Center 66
25 AP0074441AvBD-5, chicken avian beta defensin) Chicken Center 66
26 AP0266323Piscidins Fish Center 66
27 AP0017933Human neutrophil peptide-4 (Alpha def) Human Center 57
28 AP0017431Guinea pig neutrophil cationic peptide 1 Guinea pig Center 49
29 AP0273355Piscidin Fish Center 43
30 AP0016028Dermaseptin-S4 Frog Center 40
31 AP0018032Human defensin 5 (alpha defensin) Human Center 40
32 AP0022232RatNP-1 (rat alpha defensin,) Rat Center 40
33 AP0022332RatNP-2 (rat alpha defensin) Rat Center 40
34 HR2P36HR2 region of MERS-CoVSynthetic Center 39
35 AP0034025Chrysophsin-2 Fish Center 38
36 AP0018132Human defensin 6 Human Center 37
37 AP0026022Maculatin 1.1 Frog Center 37
38 AP0283043ccBD (Channel Catfish beta def) Fish Center 33
39 AP0022531RatNP-4 (rat defensin) Rat Center 31