Table of Contents
Advances in Biomaterials
Volume 2014, Article ID 351248, 12 pages
http://dx.doi.org/10.1155/2014/351248
Research Article

Evaluation of Gellan Gum Film Containing Virgin Coconut Oil for Transparent Dressing Materials

1School of Fundamental Sciences, University Malaysia Terengganu, 21030 Terengganu, Malaysia
2Department of Plant Science, Kulliyyah of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia
3Institute of Marine Biotechnology, University Malaysia Terengganu, 21030 Terengganu, Malaysia

Received 1 September 2014; Revised 10 December 2014; Accepted 11 December 2014; Published 30 December 2014

Academic Editor: Viness Pillay

Copyright © 2014 Nur Arifah Ismail et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined the potential of virgin coconut oil (VCO) incorporated in gellan gum (GG) films as a dressing material. Pure GG film is extremely brittle and inclusion of 0.3% (w/w) VCO in the GG film (GG-VCO3) improved the toughness ( J g−1) of the composite films. Swelling properties and water vapor transmission rates of GG-VCO composite films decreased, whereas thermal behavior values increased upon the addition of higher concentrations of VCO. Cell studies exhibit that the VCO is noncytotoxic to human skin fibroblast cells (CRL2522) with limited cell growth observed on GG-VCO3 films at 1,650 cells/well after incubation for 72 h which could be due to hydrophobic influence of the material surface. The qualitative and in vitro quantitative antibacterial results revealed that VCO does not possess strong bacterial resistance against all four tested bacteria, that is, two Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and two Gram-negative bacteria (Pseudomonas aeruginosa and Proteus mirabilis).