Function and Regulation of the Plant COPT Family of High-Affinity Copper Transport Proteins
Conserved features in CTR/COPT family proteins. (a) CTR/COPT topology and conserved domains and motifs. The three TMDs are shown in blue. Green boxes represent extracellular methionine/histidine-rich motifs and red boxes indicate cytoplasmic cysteine/histidine motifs. (b) Representation of the assembly of CTR/COPT trimers in the membrane. The model highlights the role of methionines in the mechanism of copper transport. Only TMDs 1 and 2 have been represented for simplicity.