Research Article
Synthesis and Antimicrobial Studies of Pyrimidine Pyrazole Heterocycles
Table 5
In vitro combination of compound 5j with polyene (AmpB, NYS) against A. fumigatus.
| | Strain | MIC (µg/mL) | FIC index | Interpretation | | 5j | AmpB | NYS | AmpB + 5j | NYS + 5j | AmpB + 5j | NYS + 5j | AmpB + 5j | NYS + 5j |
| | ITCC 4517 | 250.00 | 1.95 | 3.90 | 1.56/6.25 | 3.12/12.50 | 0.83 (0.8 + 0.03) | 0.85 (0.8 + 0.05) | IND | IND | | ITCC 1634 | 500.00 | 1.95 | 3.90 | 3.12/12.50 | 6.25/25.00 | 1.62 (1.6 + 0.02) | 1.65 (1.6 + 0.05) | IND | IND | | VPCI 190/96 | 500.00 | 1.95 | 3.90 | 1.56/3.12 | 3.12/12.50 | 0.81 (0.8 + 0.01) | 0.83 (0.8 + 0.03) | IND | IND |
| | Geometric mean | 396.85 | 1.95 | 3.90 | 1.96/6.24 | 3.93/15.70 | 1.03 (1.00 + 0.3) | 1.05 (1.00 + 0.5) | IND | IND |
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IND: indifference.
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