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Advances in Chemistry
Volume 2014 (2014), Article ID 340786, 5 pages
Research Article

Cobalt(II) Chloride Hexahydrate as an Efficient and Inexpensive Catalyst for the Preparation of Biscoumarin Derivatives

Young Researchers and Elites Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran

Received 23 June 2014; Accepted 26 September 2014; Published 12 October 2014

Academic Editor: Georgia Melagraki

Copyright © 2014 Mohammad Reza Nazarifar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cobalt(II) chloride hexahydrate (CoCl2·6H2O) has been found to be an efficient catalyst for the one-pot synthesis of biscoumarin derivatives through a combination of aromatic aldehydes and 4-hydroxycoumarin in aqueous media at 70°C. Several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were used in the reaction and in all cases the desired products were synthesized successfully. The present approach offers remarkable advantages such as short reaction times, excellent yields, straightforward procedure, easy purification, environment friendliness, and low catalyst loading.