Table of Contents
Advances in Chemistry
Volume 2014, Article ID 471950, 13 pages
Research Article

Synthesis and Characterization of Tolvaptan Impurities

R and D, Mylan Laboratories Ltd., Plot No. 31, 32, 33 and 34 A ANRICH Industrial Estate, Bollaram, Jinnaram, Medak, Andhra Pradesh 502325, India

Received 12 May 2014; Accepted 26 June 2014; Published 10 July 2014

Academic Editor: Atsushi Ohtaka

Copyright © 2014 Madhuresh Kumar Sethi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Twenty-six possible as well as observed impurities during the preparation of Tolvaptan have been identified, prepared, and characterized by HPLC (high performance liquid chromatography), NMR (nuclear magnetic resonance), and mass spectra. Control of these impurities, formed during various stages of Tolvaptan preparation, has been mentioned in this paper.