Table of Contents
Advances in Chemistry
Volume 2014, Article ID 736417, 6 pages
Research Article

A Conformational Model for MTPA Esters of Chiral N-(2-Hydroxyalkyl)acrylamides

1Laboratorio de Biocatálisis, Departamento de Química Orgánica y UMYMFOR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina
2INTI-CONICET, Avenida Gral. Paz 5445, Ed. 42, San Martín, B1650JKA Buenos Aires, Argentina

Received 19 May 2014; Revised 13 July 2014; Accepted 13 July 2014; Published 10 August 2014

Academic Editor: Daniel Glossman-Mitnik

Copyright © 2014 Eduardo M. Rustoy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The absolute stereochemistry of novel chiral N-(2-hydroxylalkyl)acrylamides prepared by a lipase-catalyzed resolution was successfully determined by 1H NMR of their MTPA esters. The method was validated for this particular case by computational experiments.